NUCLEOME THERAPEUTICS, is using breakthrough genomics technologies to discover first-in-class antibody therapeutics for inflammatory diseases. The approach is based solely on human disease genetics and biology. Nucleome is able, for the first time, to reveal molecular mechanisms of disease and select drug targets using human genetic variants in the non-coding genome that alter gene expression. The Company’s proprietary 3D genomics combines lab and machine learning technologies which can be applied to any set of disease-associated variants. Nucleome Therapeutics was founded by leading experts in gene regulation from the University of Oxford and is backed by top tier life science investors. The role: Nucleome Therapeutics Operational team is growing Operational Team and looking to add a LABORATORY MANAGER. You will have an integral role in the day to day running of our state-of-the-art laboratories. The role will support the efficient and smooth running of the research laboratories. This will include contractor management, equipment maintenance schedules (planned and unplanned), stock control, placing purchase orders, sample management, waste management. The role will require management of laboratory COSHH assessments and laboratory process and equipment risk assessments by ensuring high standards to Health and safety procedures and regulations. Key responsibilities: Day to day management of the Laboratory Ensure quality and compliance of laboratory processes liaising with scientists to remedy issues and identify training opportunities Monitor, author and approval of laboratory SOPs to ensure scientists understand and adhere to the required processes Management of laboratory and equipment cleaning schedule, delegating tasks as appropriate Support and resolve laboratory related requests raised by the scientific teams Ownership of requests via the Laboratory tracker ensuring timely management and resolution SME of LIMS sample management system, input of samples to the sample management system on delivery. Audit and Maintenance of sample management system. Person Designated for the management of human tissues as part of the HTA (Human Tissue Act). Ensuring compliance to the HTA licensing by supporting audits and review of process and procedures Line Management of Laboratory Assistant Line management responsibilities including day to day task allocation, performance management and development Laboratory procurement Management of stock control to ensure laboratory consumables, reagents and materials are readily available for the Scientific teams Placing Purchase orders for laboratory consumables, reagents and materials in line with approved limits. Managing the order tracking and working with Procurement on order lead-times Approval of Purchase orders in line with Laboratory budget Managing stock levels of general consumable lab items, maintaining reorder points of critical laboratory supplies Receipt of deliveries for goods in process, checking the correct item is delivered and right quality for Finance to process invoice payments Procurement, supply, and installation of laboratory equipment to ensure the lab is appropriately equipped for the scientific demands of the company Laboratory equipment maintenance Coordination of equipment calibrations including annual pipette calibrations and routine repairs Liaising with external service engineers for preventative maintenance, coordinating bookings, onsite inductions and filing service reports Management of equipment asset inventory, updating service records, maintenance schedules and supporting service contract renewal process Review and approval of service and calibration reports. Review and approval of Equipment maintenance and Service contracts, ensuring the right level of cover for the equipment maintenance and calibrations. Laboratory waste management Responsible for ensuring laboratory waste is disposed of efficiently and safely liaising with specialist waste contractors Oversee special waste disposal for hazardous material and clinical waste to conform to current legislation Identify and support processes for greener methods for waste reduction and management Health, safety and environment Management of all laboratory risk assessments in line with current legislation Management of COSHH assessments for new chemicals for the laboratory, ensuring conformity to current legislation Author and owner of SOPs for general laboratory equipment (i.e. Autoclave) Support initiatives to reduce our impact on the environment Experience : Experience in a laboratory environment and of laboratory stock control and inventory systems Experience and knowledge of Health and Safety requirements in a laboratory environment