Research Assistant: £32,296 to £33,882 per annum Research Associate: £34,866 per annum Newcastle University is a great place to work, with excellent benefits including a generous holiday package, great pension schemes, and health and wellbeing initiatives. Closing Date: 05 January 2025 The Role This post is an exciting opportunity for a Research Assistant/Associate to work on a project investigating the molecular mechanisms of cardiovascular disease during prostate cancer therapy, funded by the JGW Patterson Foundation. The project aims to generate pilot data to support further funding applications. We are looking for a motivated researcher to perform transcriptomics and functional assays in human cardiomyocytes treated with prostate cancer hormone therapy drugs. The position is based at our Newcastle Upon Tyne campus, with state-of-the-art facilities and excellent transport links. You will be a member of the Newcastle University Biosciences Institute and research themes focused on 'Cells, Genes and Molecules' and 'Vascular Biology and Medicine'. You will work with a collaborative team of RNA biologists and researchers from Newcastle, Leeds, and Sheffield, providing an opportunity to develop skills in cardio-oncology research and knowledge in a multidisciplinary area, with a possibility to learn basic bioinformatics skills. What do we need from you? To apply, provide your CV and a cover letter outlining your suitability for the role with examples that meet the essential criteria in knowledge, skills, and experience as listed in the job description. Focus your cover letter on: Regulation of gene expression, especially RNA transcription and processing Molecular biology techniques such as nucleic acid extraction, PCR, and Western blotting Mammalian cell culture, including drug treatment and nucleic acid transfection Leading the experimental planning and coordination of a laboratory-based research project This post is fixed term for 12 months. For inquiries, contact Dr Sara Luzzi at sara.luzzinewcastle.ac.uk. Key Accountabilities Contribute ideas and enhancements to the technical or methodological aspects of studies, providing 'added value' Develop and carry out specified projects using appropriate techniques Determine appropriate methodologies for research, with advice and support when required Contribute to and develop grant applications and proposals for funding Write and disseminate research findings through publications and presentations Possibly supervise final year undergraduate projects and support postgraduate students Work with support staff and interact with academic members of the Institute Participate in public engagement activities Conduct literature reviews relevant to the project Manage laboratory consumables and maintain laboratory records Participate in the research group’s activities The Person Knowledge, Skills and Experience Teamwork and rapid skill acquisition ability Subject knowledge in transcription and RNA processing Advanced skills related to research projects Analytical and problem-solving capabilities Clear communication skills Research experience with transferable skills Laboratory experience in cell and molecular biology techniques Ability to formulate hypotheses and develop contingency plans Understanding of laboratory safety protocols Adaptability to changing project needs Desirable Experience in transcriptomics and bioinformatics Experience with cell line immunostaining or colorimetric assays Knowledge of cancer or cardiovascular biology Attributes and Behaviour Professional attitude and initiative Task prioritization ability Commitment to research integrity and ethical guidelines Good interpersonal skills Flexibility in using communal equipment Qualifications Good honours degree in life/biomedical science for Research Assistant PhD in relevant field for Research Associate Newcastle University values diversity and is an equal opportunities employer, actively promoting career development and inclusivity. Requisition ID: 27802