Location:
Cambridge, Cambridgeshire, England
Functional Expertise:
Research & Development
CK Group is partnering with Nxera Pharma to recruit a Membrane Protein Biochemist for their Protein Sciences division.
This role is ideal for a scientist passionate about GPCRs and membrane protein biochemistry. It offers a unique opportunity to contribute to cutting-edge drug discovery in a collaborative and innovative environment.
Applications are welcomed from candidates with a PhD in Biochemistry, Biophysics, or related fields, with proven experience in membrane protein expression and purification.
Location:
Granta Park, Cambridge.
About the company:
Nxera Pharma (formerly Sosei Heptares) is a biopharma company leveraging technology to develop new medicines for patients with unmet needs globally. Their pipeline focuses on CNS, GI, immunology, metabolic disorders, and rare diseases, utilizing their GPCR-targeted structure-based drug discovery platform, NxWave.
Based in Cambridge, UK, Nxera has developed capabilities across discovery and translational medicine to advance multiple programs from pre-clinical to early clinical stages.
About the role:
You will focus on expressing and purifying challenging membrane proteins for biochemical, biophysical, and structural studies to support Nxera’s drug design process.
Responsibilities include:
* Expressing and purifying membrane proteins for various applications
* Designing and engineering expression constructs for mammalian and insect cells
* Optimizing protein expression and purification workflows
* Characterizing purified proteins using techniques like fSEC, DLS, SEC-MALS, DSF, FP
* Reconstituting proteins in membrane mimetics
* Assembling and purifying protein complexes
* Staying updated with scientific literature and developing new methodologies
* Presenting results effectively to teams
* Collaborating with scientists to progress membrane protein targets
* Maintaining detailed laboratory records
Skills and Experience:
* PhD in biochemistry, biophysics, or related field
* Skills in designing membrane protein constructs
* Experience in expressing proteins in mammalian and insect cells
* Expertise in purification protocols
* Understanding of structural and biophysical studies
* Proficiency in biochemical and biophysical techniques
* Ability to use in silico methods like AlphaFold
* Experience with molecular graphics software (e.g., Pymol, Chimera)
* Experience in assay development for drug discovery
* Experience with membrane protein reconstitution
What’s in it for you?
* State-of-the-art R&D centre in Cambridge
* Competitive salary with bonuses
* Eligible for Restricted Stock Units
* 26 days annual leave plus holidays
* Employer pension contributions
* Private medical insurance and wellness benefits
* Income protection and death benefits
Apply:
Applicants must have UK work entitlement. Please quote reference 131454 in all correspondence.
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