Short summary
An exciting Senior Bioinformatician post is available in the Cancer Dynamics Laboratory. The post holder would work across multiple on-going projects of the lab, including a dedicated role within the MANIFEST project (“Multiomic ANalysis of Immunotherapy Features Evidencing Success and Toxicity”), a newly formed ambitious multi-stakeholder consortium involving academic, industry and NHS partners to deliver deep multiomic profiling for patients with cancer undergoing immunotherapy. The MANIFEST consortium represents a diverse group of UK-wide experts in cancer research and clinical care comprising major NHS trusts, academic institutes and universities, and industry partners.
The successful candidate will join the bioinformatics team at the Cancer Dynamics Laboratory. This role will involve leveraging data from the MANIFEST, TRACERx Renal ( and PEACE ( renal cancer and melanoma) studies. The primary responsibility of the post-holder will be to perform bioinformatics discovery analyses aimed at identifying genomic and transcriptomic features that influence responses and resistance to immunotherapy.
Key Responsibilities
These include but are not limited to:
• To work within the bioinformatics team of the Cancer Dynamics lab, and collaborating with other groups at the Institute, academic, clinical and industry partners of MANIFEST.
• To conduct analyses of genomic and transcriptomic data, using established pipelines.
• To analyse DNA sequencing data, identifying somatic mutations, copy number aberrations, and neoantigens.
• To analyse RNA sequencing data, performing immune deconvolution and identifying gene expression signatures.
• To evaluate and provide state-of-the-art tools, databases, protocols and methods necessary for the analysis of above-mentioned biological data.
• To liaise and coordinate between the project collaborators which include clinicians, cancer biologists, machine learning experts and mathematical modellers.
• To document all analyses in an accurate, timely and clearly presented manner, and use this to prepare data summaries and reports as and when required.
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Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
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