Direct message the job poster from Resolution Therapeutics
We are recruiting a Process Development (PD) Senior Scientist to join our Manufacturing and Technical operations team. This London-based position is a full-time opportunity, on a permanent basis.
Resolution Therapeutics (RTx) is a biotechnology company developing Regenerative Macrophage Therapies (RMT) to treat inflammatory and fibrotic diseases. The company’s technology is based on world-leading research from Prof. Stuart Forbes (Edinburgh’s Centre for Regenerative Medicine) and Prof. John Campbell (ex-SNBTS) and is backed by investment from Syncona, Europe’s leading life science investor.
In this role you will drive the late-phase development of our manufacturing process to generate Regenerative Macrophage Therapies for liver disease, as well as development and implementation of our technology for other therapeutic targets.
You will work collaboratively with internal teams and external partners to deliver programs of work to bring these much-needed medicines to patients.
Scientific capability
We are seeking an experienced and highly motivated scientist to join the Process Development team, part of the Manufacturing and Technical Operations group, developing our manufacturing technology. This role is laboratory-based. Working in a matrix environment, this position will require interaction across a range of different company functions, including discovery and clinical groups.
Key responsibilities include:
1. Driving the development of manufacturing technology for application to the RTx portfolio and progression of the pipeline to clinic; focusing on autologous cell therapy approaches but also working flexibly around other processes as required.
2. Delivery of Process Development activities including experimental design and execution in the lab, including completion of written reports.
3. Review and interrogation of data and facilitating new methods for data management and modelling where necessary.
4. Reporting and presenting results in external and internal meetings.
5. Assisting in resource management for the Process Development team and setting priorities in line with wider strategic objectives.
6. Supervising lab-based activities of junior members of the team within the London facility.
7. Coaching and supporting development of others as appropriate.
8. Playing a leading role in the continual improvement of processes, including a focus on data collection and handling for manufacturing process understanding and development.
The successful candidate must have the following:
1. A Bachelor’s or Master’s degree in a field related to cell and gene therapies.
2. A minimum of 3 years’ industrial experience working in process development or relevant area, preferably relating to cell therapies.
3. Proven experience in the development of advanced therapy cell-based technologies.
4. Knowledge of data analysis and the appropriate application of statistical analysis.
5. Experience of working within a multidisciplinary team.
6. Scientific expertise and excellence in the laboratory.
7. A Quality mindset.
8. The ability to travel between our sites or for business reasons.
9. A good understanding of medicine development and regulatory requirements during the cell therapy product lifecycle.
10. Experience of activities and procedures required to ensure a safe working environment.
11. Willingness to work hard, and at times under pressure, as part of a high performing team.
The following are also desirable but not essential:
1. A PhD or similar levels of hands-on experience in a subject related to advanced therapies.
2. An understanding of our focus area, including macrophage biology, liver disease, inflammation and fibrosis.
3. Experience of designing and implementing in-process control strategies to support cell therapy process development and/or GMP manufacturing.
4. Experience of performing technology transfer activities to external sites.
5. Experience in the production and/or application of mRNA in advanced therapies.
6. Knowledge or experience in the application of cell therapy manufacturing equipment.
7. Contribution towards a regulatory file submission.
8. An understanding of GMP manufacture and working in a cleanroom.
9. Experience of Process Development for late phase clinical trials or commercialisation, including process qualification and validation.
10. Knowledge of Formulation, Fill and Finish of drug products.
11. Understanding of the drug development pathway, delivery of manufacturing technologies for clinical application and experience of scaling up/out processes for various clinical phases.
12. Application of Quality by Design.
13. An understanding of the Human Tissue Act and application in cell therapy research.
What we offer you:
Resolution is committed to fostering a supportive and inclusive work environment that values the well-being of employees. We offer an excellent benefits package and family-friendly policies that are in line with our company Behaviours.
We believe in creating a workplace culture that supports your personal and professional growth. Join our team to be part of a dynamic and innovative environment that prioritizes your well-being and success.
All applications received will be dealt with confidentially and subject to the company recruitment and selection processes.
Employment is subject to satisfactory pre-employment checks including right to work in the United Kingdom.
To apply, or ask any questions, please send a covering letter and CV to:
careers@resolution-tx.com
Seniority level
Mid-Senior level
Employment type
Full-time
Job function
Research, Analyst, and Information Technology
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