Amphista Therapeutics is focused on transforming the lives of patients with severe diseases including cancer. The company is applying its proprietary Amphista degrader platform to advance new approaches in targeted protein degradation (TPD). They aim to address the challenges faced by earlier stage TPD research and to realise the full therapeutic potential of this transformational approach. Founded by Advent Life Sciences, Amphista is a spin-out of TPD expert Professor Alessio Ciulli’s laboratories at the University of Dundee. The Company has raised over $60M to date and is funded by leading life science investors including Forbion, Gilde Healthcare, Novartis Venture Fund, Advent Life Sciences, Eli Lilly & Company and The Dementia Discovery Fund. For more information, please visit: www.amphista.com
Position:
In this role, the Director / Sr.Director DMPK will lead and contribute to Amphista’s protein degrader drug discovery and development programs and have a significant impact on the success of the company and R&D strategy.
Leading and working within project and functional teams, you’ll help drive project advancement and decisions from the H2L / lead optimisation phases through to candidate selection and development across the Amphista portfolio. As a key part of Amphista R&D leadership, you’ll work closely with the SVP of Chemistry, project teams, medicinal chemistry, biology, pharmacology and development leaders as well as senior leadership including CSO, CDO and others.
Requirements:
Leadership and Management
* As part of senior R&D leadership contribute to setting and delivery of goals and strategic R&D direction for company to deliver valuable medicines addressing unmet clinical need which also showcase the unique benefits of Amphista technology.
* Manage a team of external DMPK consultants to enable delivery of project goals and the delivery of candidate molecules for development.
* Potentially lead a team of scientists, with specific responsibility to undertake regular reviews, provide advice, support and training & development for direct report.
* Responsible for leading, motivating and developing staff within and beyond line management responsibility.
* Lead matrix team to achieve project goals on time and on budget working closely with project management functions.
Governance
* Ability to work across functions to optimise processes and activities to deliver therapeutic projects and other scientific activities to milestones on agreed deadlines.
* Propose and oversee academic, CRO and other industry-led collaborations to advance a range of programs.
* Work closely with project management functions and senior R&D leadership team to ensure therapeutic programs are progressed and delivered to plan.
Standards and Compliance
* Responsible as a senior R&D leader for ensuring all activities, records and data are clearly recorded, kept up to date and in compliance with regulatory and H&S requirements.
* Create and present plans and results in a range of verbal and written channels to Amphista R&D leadership and programme teams, including preparing and writing-up protocols, methods and reports as required.
Change and Performance
* Responsible for leading, developing and introducing new strategies and ways to advance specific projects or systems.
* Maintain good awareness of the internal & external developments in the field and apply these to each project:
* Proactively suggest and evaluate new techniques.
* Design and implement new ways of working that have a direct impact on data quality & productivity.
* Responsible for driving and developing specific discovery programs, scientific strategy and workstreams to ensure that the IP position of the platform and portfolio is developed to develop Amphista’s leadership position and unique IP estate.
Operational and Technical
* Support drug discovery projects by development of DMPK strategy for degrader bRo5 compounds to deliver candidate molecules for development.
* With third party CROs manage a range of DMPK assays and timely delivery of data from these assays to characterize lead molecules to support their development and differentiation.
* Responsible for monitoring, measuring and reporting on scientific issues, opportunities and developmental plans and achievements within agreed formats & timescales.
* Maintain comprehensive up to date knowledge of competitor landscape in TPD and therapeutic indication to ensure portfolio of projects are differentiated.
* Undertake any other reasonable duties allocated to the role.
Other information:
What’s on offer
* Competitive salary
* Flexible Benefits including Private Medical Insurance, Life Assurance at 4 x Salary, Critical Illness Cover and a Health Cash Plan
* Discretionary Bonus Scheme
* Allocation of Growth Shares
* Pension scheme with 5% employer matched contribution
* 25 days holiday + bank holidays
* Holiday buy scheme
More about Amphista
Amphista’s approaches use completely novel mechanisms to build on all the advantages of TPD while directly addressing the emerging limitations of existing TPD strategies to expand the utility of the field. We have shown our approach has the potential to be superior to all other TPD approaches (PROTACs, molecular glues etc) improved druglike properties and reduced tumour resistance potential. We have a range of projects in the discovery phase, initially focused on oncology with potential to expand into other therapy areas including CNS disease & immunology.
Initially founded from the laboratory of Professor Alessio Ciulli (University of Dundee) our team comprises both academic and drug discovery pioneers of the TPD field and a growing R&D team focused on advancing a portfolio of medicines to the clinic using our proprietary next generation TPD technologies. We are continuing to grow and are looking for a key hire to expand our screening and assay teams.
The Amphista team comprises highly experienced drug discovery and TPD experts across both biology and chemistry disciplines, creating the ideal learning environment to advance your scientific career development quickly. This is an exciting opportunity to join a fast growing and dynamic company operating at the cutting edge of protein degradation-based drug discovery to develop first-in-class medicines to treat cancer and other areas of high unmet medical need.
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