Research Associate
Prof Payam Gammage
The impact of mitochondrial DNA mutation on tumour microenvironments
Salary: from £36,851 to £45,357 subject to experience, plus relocation allowance and visa costs if required.
Contract term: Fixed up to October 2027 (external funding end)
About us
The CRUK Scotland Institute, where the lab is based, is a world-leading cancer research institute, situated in the vibrant city of Glasgow in Scotland and hosting approximately 60 postdoctoral researcher scientists at any one time. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned in vivo modelling of tumour growth and metastasis.
Project outline
The majority of cancers bear mutations of the mitochondrial genome. Our recent work has identified recurrence and selection of these mutations in tumours (Gorelick et al., 2021, Nature Metabolism) and forthcoming papers from our lab show that a key impact of these mutations is altered tumour metabolism, driving divergent tumour immune microenvironments that mediate susceptibility to treatment (Mahmood et al., 2024, Nature Cancer). In the Mitochondrial Oncogenetics Lab at CRUK SI, we have developed and applied advanced mitochondrial genome engineering techniques to create models of mitochondrial mutant cancer that we study in a variety of contexts.
We aim to develop a broad understanding of the impact mtDNA mutations exert within and between tissue lineages, and this project will define the impact of recurrent mtDNA mutations on cancer metabolism, tumour growth, and the immune microenvironment.
The successful applicant will be highly enthusiastic, driven to succeed, and already have or soon be completing a PhD in mitochondrial biology, cancer, or immunology. Experience of any of the following: single-cell approaches, cancer genomics, in vivo cancer modelling, and/or quantitative approaches to metabolic science are desirable but not essential.
For informal enquiries, please email payam.gammage@glasgow.ac.uk
Equality, Diversity and Inclusion
Our overarching research ethos at the Institute is about excellence, honesty, openness, accountability, and integrity. The diversity of our staff and students is also what makes the Institute such a vibrant place to work and advance discoveries in cancer research. Family-friendly policies, our collaborative ethos, a focus on good mental health and well-being, and opportunities for all help to create an enjoyable and inclusive workplace where your voice matters.
Employee Benefits
* Competitive salary
* 40.5 days annual leave including bank holidays (pro-rata)
* Defined Contribution pension scheme
* Life Insurance scheme
* Employee Assistance Programme
* Season ticket loan
* Additional maternity pay at 6 month’s full pay (subject to service)
* Shared parental leave
* Cycle to work scheme that could save you 26-40% on a bike and accessories.
* Access to Employee benefit schemes with discounts on supermarkets, cinema, travel, and much more.
* On-site secure parking
All applications must be made via our website at: https://www.crukscotlandinstitute.ac.uk/careers/scientific-officers.html
Closing Date: 7th February 2025
Job Types: Full-time, Fixed term contract
Contract length: 30 months
Pay: £36,851.00-£45,357.00 per year
Benefits:
* Canteen
* Casual dress
* Company pension
* Cycle to work scheme
* Enhanced maternity leave
* Health & wellbeing programme
* Life insurance
* On-site parking
Schedule:
* Day shift
* Monday to Friday
Work Location: In person
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