Computational Chemistry Expert Researcher
Salary: £29.52 - £39.36 per hour / Location: Bracknell Hybrid role / Duration: 12-month Temporary position
About Our Client
Our client is a leading small molecule drug discovery group with responsibilities spanning from target identification to candidate selection for clinical studies. They are on a mission to grow their diverse team of scientists.
We are seeking a highly skilled and motivated computational chemistry expert to join our dynamic team in the UK. The ideal candidate will have a strong background in applying computational tools to accelerate drug discovery programs and a forward-looking vision for the future of drug discovery. You will work on active drug discovery programs, leveraging computational tools to design compounds that meet the project's goals.
Responsibilities
1. Own all aspects of the project SAR and communicate findings with a multi-site team.
2. Lead understanding of ligands, target structure, and 3D ligand-target interactions to design compounds to drive progress toward project goals.
3. Partner with a wider project team to ensure collective success.
4. Develop or integrate in silico methods where necessary to solve project issues.
5. Stay updated on the latest developments in AMR and computational chemistry.
6. Promote the use of computational approaches and educate others in your areas of expertise.
Qualifications
1. PhD or equivalent in Medicinal Chemistry, Computational Chemistry, Bioinformatics, or related field plus at least 3 years of experience in a drug discovery setting.
2. Extensive experience with computational chemistry software and tools (in particular Schrödinger Suite, MOE, OpenEye, or Cresset tools).
3. Experience in structure-based drug design, especially from fragment starting points.
4. Knowledge of programming languages, particularly Python, or workflow tools such as Knime or Pipeline Pilot.
5. Knowledge of drug discovery processes and pharmaceutical research.
6. Demonstrated critical thinking and problem-solving skills with the ability to work independently and as part of a larger drug-hunting team.
Additional Skills/Preferences
1. Experience in or knowledge of antibacterial drug discovery and development.
2. Familiarity with the fundamental concepts of organic chemistry, medicinal chemistry, and ADME.
3. Examples of impactful contributions to small-molecule drug discovery programs with cheminformatics, structure-based drug design, physics-based simulation methods, or ab initio calculations.
4. Strong evidence of research output including peer-reviewed publications, conference presentations, patents, blog posts, GitHub Repos, etc.
Should you require any support or assistance, please contact your local Gi Group office.
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