Job summary We seek an ambitious, innovative individual with a specific interest in lymphoma, clinical research and/or early phase clinical trials to act as sub-investigator for a growing portfolio of complex clinical trials.The role offers an exciting opportunity to work with an established, multidisciplinary research team to deliver innovative research. With consultant oversight, you will be responsible for seeing new referrals, follow-ups & managing patients throughout all aspects of their trial experience. You will take an active role in local and regional meetings to identify and define suitable trial options for patients. You will also be involved with managing NHS patients through our lymphoma clinics, with approximately 50% of your time being dedicated to research, professional development and teaching.This is a 10 session non-training post. It is suitable for individuals post-FY2 through to those completing specialist training in Oncology or Haematology, and who wish to gain further experience in lymphoma alongside experimental medicine and early-phase trials, including first-in-human trials, advanced immunotherapies and translational research.Applicants must be able to start early August 2025; applicants requiring GMC sponsorship via MTI recruitment processes will not be considered on this occasion.Salary will be on the NHS scale in line with appropriate clinical experience. Interested candidates are encouraged to discuss this ahead of any application. Main duties of the job The portfolio includes a diverse range of lymphoma clinical trials. Following training, you will be expected to participate in these studies as a sub-investigator and associate principal investigator. These include phase I-III trials of small molecule inhibitors, next-generation chemotherapy, novel immunotherapies, CAR-T-cell therapy and translational studies.You will be involved in managing all aspects of lymphoma trial patients (both in outpatient & inpatient settings), through new patient consultation, consent & screening patients & reviewing patients at follow-up appointments.You will be expected to attend safety review committee meetings to discuss trial patients. This will involve close liaison with the Principal Investigators. In addition, you will interface with external stakeholders such as CROs & pharmaceutical sponsors.You will be expected to undertake the administrative duties associated with the care of our patients. You will be given opportunities and will be encouraged to be involved in the development & planning of new studies.Up to 50% of your time will be dedicated to lymphoma research, with scope to develop a range of projects according to personal interests. You will be expected to be involved in writing papers & reviews, and there is potential to present your research work nationally and internationally. Participation in established clinical research training schemes will be encouraged. You will also be required to undergo an annual appraisal. About us The Christie is one of Europe's leading cancer centres, treating over 60,000 patients per year. We are based in Manchester and serve a population of 3.2 million across Greater Manchester & Cheshire, but as a national specialist around 15% patients are referred to us from other parts of the country. We provide radiotherapy through one of the largest radiotherapy departments in the world; chemotherapy on site and through 14 other hospitals; highly specialist surgery for complex and rare cancer; and a wide range of support and diagnostic services. We are also an international leader in research, with world first breakthroughs for over 100 years. We run one of the largest early-phase clinical trial units in Europe with over 300 trials every year. Cancer research in Manchester, most of which is undertaken on the Christie site, has been officially ranked the best in the UK.The lymphoma team have the largest portfolio of both commercial and non-commercial lymphoma trials in the UK. You will support an established, dynamic, multidisciplinary research team to deliver innovative treatments to patients from a wide geographic area. You will supported to develop and advance your own research skills and interests.Facilities include a dedicated NIHR Clinical Research Facility with inpatient beds, outpatient suites, trials pharmacy, laboratory & an administrative floor. The close links with the Cancer Research UK Manchester Institute provide GCLP compliant laboratories. Date posted 04 March 2025 Pay scheme Hospital medical and dental staff Grade Doctor - other Salary £49,909 to £70,425 a year per annum Contract Fixed term Duration 12 months Working pattern Full-time Reference number 413-MD-C2024-24043-LP-A Job locations Lymphoma - Q00517 Manchester M20 4BX Job description Job responsibilities ORGANISATIONAL ARRANGEMENTSThis post is for 40 hours per week to provide clinical research fellow support to The Christie Lymphoma Team. It is based at the main Christie Hospital site in the department of Medical Oncology and the NIHR Manchester Clinical Research Facility (CRF). This position is designed for individuals who wish to increase their experience in early-phase clinical trial research and/or lymphoma and are interested in to pursuing a specialist career in medical oncology, haematology or clinical oncology and clinically-orientated research. Role PurposeThe clinical research fellow post at the Christie Hospital NHS Foundation Trust will support early-phase clinical research in lymphoma under the supervision of Dr Kim Linton and Dr Beth Phillips. The post holder will be involved in all aspects of care for patients enrolled on early-phase clinical trials and will work in close liaison with other members of the multidisciplinary team. The role will support the Lymphoma Research Team: The Lymphoma Research Team aims to develop and perform internationally competitive, practice-changing studies of relevance to patients with lymphoma, and to enhance our existing national and international reputation. In 2022-2023, we had the largest portfolio of open lymphoma trials in the UK, both commercial and non-commercial, and were the second-highest UK recruiter to commercial studies. Recent successes include the first UK site to open and recruit a patient to the NX-5948-301 BTK degrader trial, top UK recruiter in the ME-401 trial and leading the field in new bispecific antibody trials as first site to screen a patient for Janssen LYM001 trial, first UK site to consent a patient to GCT3013-02 using epcoritamab in combination regimens and first site globally to dose a patient with subcutaneous odronextamab. The team also actively contributes to the UK Lymphoma Research Group (formally NCRI) as sub-group chairs/representatives and lead on a number of non-commercial trials. Examples include the ongoing international phase 3 RADAR trial, evaluating brentuximab vedotin as frontline treatment for early-stage Hodgkin lymphoma, and the randomised phase 2 REFRACT trial evaluating multiple novel therapies such as epcoritamab-lenalidomide against standard of care. Members of the team are regularly invited to present trial data at major international conferences (ICML, ASH, ISHL, EHA), have authored/co-authored trial publications in high-impact journals (NEJM, J Clin Onc, Lancet Oncology, Lancet Haematology, Blood) and have acted as expert reviewers for NICE and EORTC. The team has an expanding portfolio of immunotherapy trials, with a major interest in developing bispecific antibody and CAR-T therapy for lymphoma, collaborating closely with the advanced therapies team within the Trust In 2012, data from named-patient studies of brentuximab vedotin performed at the Christie were used in submissions to the European Medicines Agency resulting in provisional licensing of the drug that can now be used across the EU in patients with relapsed/refractory CD30ve lymphomas. Updated results of the same patient cohort were used in 2015 to support continued access to brentuximab vedotin via the Cancer Drugs Fund and was also used as evidence to NICE who undertook a review of the drug in 2016. This work was undertaken by a previous research fellow under supervision by consultant colleagues illustrating the importance of this role to the Lymphoma team. One of our recent lymphoma fellows wrote the protocol, information sheet and consent form for a highly innovative study (REACT) evaluating the potential role of wearable biosensors in patients at high risk of sepsis, revised a paper now submitted for publication and was successful in a highly competitive and prestigious NIHR Clinical Fellow application. Currently there are there are 32 lymphoma studies open and recruiting, with 32 in active follow up and a further 28 in feasibility or set-up stage. Of our 32 open and recruiting studies, around 40% are phase I/II studies demonstrating our commitment to early-phase research, and collaboration with ECMC network. Furthermore, referral of patients with haematological malignancies from outside of Manchester is an increasing feature of our practice with the number patients referred for consideration of clinical trials growing year on year. DUTIES AND RESPONSIBILITIESThe Christie Lymphoma Team provides expert treatment for patients with a wide range of lymphoma subtypes. Level 2-4 specialist care is provided for the Southern sector of the Greater Manchester and Cheshire Cancer network (GMCCN) (population 900,000). Close clinical collaboration exists between The Christie and the other Haematology Departments of the South sector of the GMCC Network: Macclesfield District General Hospital and Stepping Hill Hospital. Through the weekly sector MDT, virtually hosted at Christie, all newly diagnosed and relapsing lymphoma patients are discussed and all patients requiring level 2-4 therapy are referred to The Christie. There are also longstanding referral pathways from Lancashire, North Staffordshire, Chester and North Wales. In addition, the team works closely with the haematology transplant unit to provide tertiary care for stem cell transplantation to the wider North West of England and Wales (population 6 million). Job description Job responsibilities ORGANISATIONAL ARRANGEMENTSThis post is for 40 hours per week to provide clinical research fellow support to The Christie Lymphoma Team. It is based at the main Christie Hospital site in the department of Medical Oncology and the NIHR Manchester Clinical Research Facility (CRF). This position is designed for individuals who wish to increase their experience in early-phase clinical trial research and/or lymphoma and are interested in to pursuing a specialist career in medical oncology, haematology or clinical oncology and clinically-orientated research. Role PurposeThe clinical research fellow post at the Christie Hospital NHS Foundation Trust will support early-phase clinical research in lymphoma under the supervision of Dr Kim Linton and Dr Beth Phillips. The post holder will be involved in all aspects of care for patients enrolled on early-phase clinical trials and will work in close liaison with other members of the multidisciplinary team. The role will support the Lymphoma Research Team: The Lymphoma Research Team aims to develop and perform internationally competitive, practice-changing studies of relevance to patients with lymphoma, and to enhance our existing national and international reputation. In 2022-2023, we had the largest portfolio of open lymphoma trials in the UK, both commercial and non-commercial, and were the second-highest UK recruiter to commercial studies. Recent successes include the first UK site to open and recruit a patient to the NX-5948-301 BTK degrader trial, top UK recruiter in the ME-401 trial and leading the field in new bispecific antibody trials as first site to screen a patient for Janssen LYM001 trial, first UK site to consent a patient to GCT3013-02 using epcoritamab in combination regimens and first site globally to dose a patient with subcutaneous odronextamab. The team also actively contributes to the UK Lymphoma Research Group (formally NCRI) as sub-group chairs/representatives and lead on a number of non-commercial trials. Examples include the ongoing international phase 3 RADAR trial, evaluating brentuximab vedotin as frontline treatment for early-stage Hodgkin lymphoma, and the randomised phase 2 REFRACT trial evaluating multiple novel therapies such as epcoritamab-lenalidomide against standard of care. Members of the team are regularly invited to present trial data at major international conferences (ICML, ASH, ISHL, EHA), have authored/co-authored trial publications in high-impact journals (NEJM, J Clin Onc, Lancet Oncology, Lancet Haematology, Blood) and have acted as expert reviewers for NICE and EORTC. The team has an expanding portfolio of immunotherapy trials, with a major interest in developing bispecific antibody and CAR-T therapy for lymphoma, collaborating closely with the advanced therapies team within the Trust In 2012, data from named-patient studies of brentuximab vedotin performed at the Christie were used in submissions to the European Medicines Agency resulting in provisional licensing of the drug that can now be used across the EU in patients with relapsed/refractory CD30ve lymphomas. Updated results of the same patient cohort were used in 2015 to support continued access to brentuximab vedotin via the Cancer Drugs Fund and was also used as evidence to NICE who undertook a review of the drug in 2016. This work was undertaken by a previous research fellow under supervision by consultant colleagues illustrating the importance of this role to the Lymphoma team. One of our recent lymphoma fellows wrote the protocol, information sheet and consent form for a highly innovative study (REACT) evaluating the potential role of wearable biosensors in patients at high risk of sepsis, revised a paper now submitted for publication and was successful in a highly competitive and prestigious NIHR Clinical Fellow application. Currently there are there are 32 lymphoma studies open and recruiting, with 32 in active follow up and a further 28 in feasibility or set-up stage. Of our 32 open and recruiting studies, around 40% are phase I/II studies demonstrating our commitment to early-phase research, and collaboration with ECMC network. Furthermore, referral of patients with haematological malignancies from outside of Manchester is an increasing feature of our practice with the number patients referred for consideration of clinical trials growing year on year. DUTIES AND RESPONSIBILITIESThe Christie Lymphoma Team provides expert treatment for patients with a wide range of lymphoma subtypes. Level 2-4 specialist care is provided for the Southern sector of the Greater Manchester and Cheshire Cancer network (GMCCN) (population 900,000). Close clinical collaboration exists between The Christie and the other Haematology Departments of the South sector of the GMCC Network: Macclesfield District General Hospital and Stepping Hill Hospital. Through the weekly sector MDT, virtually hosted at Christie, all newly diagnosed and relapsing lymphoma patients are discussed and all patients requiring level 2-4 therapy are referred to The Christie. There are also longstanding referral pathways from Lancashire, North Staffordshire, Chester and North Wales. In addition, the team works closely with the haematology transplant unit to provide tertiary care for stem cell transplantation to the wider North West of England and Wales (population 6 million). Person Specification Qualifications Essential MRCP or equivalent - Qualification details and pass dates should be confirmed in the supporting information GMC registration Training Essential ICH GCP Training Management / Audit Desirable Evidence of participation in clinical audit Domicile Essential Within 30 minutes travel time to the hospital Research / Publications Essential The ability to contribute to an active research group Desirable Recent publications in peer-reviewed journals Evidence of ethical research relevant to lymphoma, oncology or acute medicine Experience Essential Minimum of 2 years' clinical practice, with experience in Medical/Clinical Oncology and/or Haemato-oncology Experience as an investigator on clinical trials Desirable 3 years' experience in Medical/Clinical Oncology and/or Haemato-oncology Teaching Desirable Experience in teaching medical students and other health professionals Personal skills Essential Evidence of clinical leadership skills Ability to work flexibly as part of a team Excellent written and oral communication skills Ability to work under pressure Capacity for staff motivation Reliable work record Person Specification Qualifications Essential MRCP or equivalent - Qualification details and pass dates should be confirmed in the supporting information GMC registration Training Essential ICH GCP Training Management / Audit Desirable Evidence of participation in clinical audit Domicile Essential Within 30 minutes travel time to the hospital Research / Publications Essential The ability to contribute to an active research group Desirable Recent publications in peer-reviewed journals Evidence of ethical research relevant to lymphoma, oncology or acute medicine Experience Essential Minimum of 2 years' clinical practice, with experience in Medical/Clinical Oncology and/or Haemato-oncology Experience as an investigator on clinical trials Desirable 3 years' experience in Medical/Clinical Oncology and/or Haemato-oncology Teaching Desirable Experience in teaching medical students and other health professionals Personal skills Essential Evidence of clinical leadership skills Ability to work flexibly as part of a team Excellent written and oral communication skills Ability to work under pressure Capacity for staff motivation Reliable work record Disclosure and Barring Service Check This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions. Certificate of Sponsorship Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab). From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab). UK Registration Applicants must have current UK professional registration. For further information please see NHS Careers website (opens in a new window). Additional information Disclosure and Barring Service Check This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions. Certificate of Sponsorship Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the UK Visas and Immigration website (Opens in a new tab). From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. Guidance can be found here Criminal records checks for overseas applicants (Opens in a new tab). UK Registration Applicants must have current UK professional registration. For further information please see NHS Careers website (opens in a new window). Employer details Employer name The Christie NHS FT Address Lymphoma - Q00517 Manchester M20 4BX Employer's website https://www.christie.nhs.uk/ (Opens in a new tab)