About the Role
This is a unique opportunity to join Nxera Pharma's Computational Chemistry team as a Senior Scientist/Lead Scientist. We are seeking a highly skilled and experienced computational chemist to contribute to the development of innovative medicines using our industry-leading GPCR-targeted structure-based drug discovery platform, NxWave.
The successful candidate will have a strong background in molecular recognition, structural and physicochemical property determinants of small molecule binding to proteins, and experience with CADD software packages. They will work closely with key stakeholders across other disciplines to define and execute computational approaches that support delivery of projects across the portfolio.
We are looking for a talented individual who can identify and help develop novel, innovative computational tools that enhance the NxWave drug design process. This includes applying a broad set of computational and cheminformatic tools, workflows, and models to extract, integrate, analyse, and visualise complex chemical, structural, pharmacological, and ADMET data.
Responsibilities include developing new computational chemistry CADD software via external collaborations, implementing customised computational tools for internal research and development, and working with generative models for GPCR structure-based artificially intelligent molecular design.
A PhD in computational chemistry, cheminformatics, or a related discipline, plus at least 3 years' experience in a collaborative multi-disciplinary medicinal chemistry research environment, is required. The ideal candidate will have strong interpersonal, oral, and written communication skills, be a team player with an inclusive, proactive, and positive mindset, and be able to communicate effectively with team members having diverse professional backgrounds.