Organisation/Company: UK Dementia Research Institute
Research Field: Neurosciences
Researcher Profile: First Stage Researcher (R1)
Positions: Bachelor Positions
Country: United Kingdom
Application Deadline: 25 Mar 2025 - 23:59 (Europe/London)
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Offer Starting Date: 28 Apr 2025
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Reference Number: MED05116
Is the Job related to staff position within a Research Infrastructure? No
Today, over 1 million people in the UK are living with dementia and related neurodegenerative disorders, such as Parkinson’s disease. The impact of these incurable and progressive conditions on individuals and their families is devastating. The cost to the economy and public services is large and growing as the UK population ages.
The UK DRI is a globally leading multidisciplinary research institute of over 900 staff investigating the spectrum of neurodegenerative disorders causing dementia, driving a step change in our understanding of neurodegeneration, and accelerating the discovery, development and delivery of interventions that will help diagnose, treat, and ultimately prevent dementia.
We are recruiting a Research Technician to provide technical support within the Skene Lab to one or more projects including combinatorial padlock-probe-amplified fluorescence in situ hybridization (coppaFISH). This method amplifies a selected panel of RNA transcripts in situ using barcoded padlock probes and reads out their barcodes combinatorially through multiple rounds of seven-colour fluorescence imaging. This method for Parkinson’s disease research enables us to simultaneously identify the cell type identity of every cell within a tissue section at a low cost, transforming our understanding of Parkinson’s disease.
What you would be doing
Building on laboratory experience and under the direction of the line manager, you will:
* Undertake training and demonstrate an aptitude for an organised, methodical approach to your work.
* Provide up-to-date technical expertise, advice and support for specialised methods appropriate to the research project.
* Select and order situ hybridisation probes for coppaFISH and execute multi-step staining protocols using coppaFISH.
* Organise, collect and QC tissue samples.
* Run software analysis pipeline for coppaFISH.
* Utilise basic methods for molecular biology (PCR, qPCR, Western blotting) on human tissue samples.
You will be dynamic, creative, and independent. You should be interested in the questions being pursued, as well as performing your work to the highest standards. Experience with running software pipelines and some computational experience will be advantageous. Having experience working with neuropathology and handling of post-mortem samples will be beneficial. While close supervision will be provided when needed, the post holder will also have opportunities in areas of expertise and in supervising rotating project students for their technical training.
Additional Information
What we can offer you
* The opportunity to continue your career at a world-leading institution and be part of our mission to use science for humanity.
* Benefit from a sector-leading salary and remuneration package (including 39 days’ annual leave and generous pension schemes).
* Access to a range of workplace benefits including a flexible working policy from day one, generous family leave packages, on-site leisure facilities and cycle-to-work scheme.
* Interest-free season ticket loan schemes for travel.
* Be part of a diverse, inclusive and collaborative work culture with various staff networks and resources to support your personal and professional wellbeing.
Further information
The role is a Full time, Fixed term (1 year) based at our White City Campus.
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