£52,762 to £62,035 per annum + Inclusive of
London Allowance
Senior Research Fellow - Bioinformatics – Extrachromosomal DNA and Tumour Evolution Scientist
The 2007 opening of the Cancer Institute in the Paul O'Gorman Building heralded a new era in cancer research and medicine at UCL. The Institute is consolidating cancer research across the campus. It fosters links between basic cancer researchers across Biomedicine, and with the clinical activities of our partner Hospitals (University College London Hospitals including Queen Square, Great Ormond Street Hospital for Children and the Royal Free Hospital). The Institute is a 40 million investment by UCL, The Wolfson Foundation, Children with Leukaemia and Atlantic Philanthropies.
About the role
We are seeking a collaborative and self-motivated bioinformatician post-doctoral fellow to work on extrachromosomal DNA (ecDNA) in a vibrant and highly collegiate environment. ecDNA are circular genomic structures that can drive ultra-high copy number amplification and correlate with poor clinical outcomes, yet their evolution, detection, and targeting remain largely unclear. This project aims to analyse ecDNA evolution over time using single-cell RNA/ATAC sequencing and to develop a ctDNA-based approach for detecting and monitoring ecDNA to support biomarker and treatment development.
About you
The successful applicant should have a proven track record of publications, have previous experience with genomics data analysis, be fluent in at least one of the following programming languages: C++, Python or R, and will have strong skills in the field of genomics and desirably one or more of the following: tumour biology, ctDNA/ blood-based biomarkers, evolutionary biology, statistics and mathematics.
What we offer
- 41 Days holiday (including 27 days annual leave, 8 bank holidays and 6 closure days)
- Defined benefit career average revalued earnings pension scheme (CARE)
- Cycle to work scheme and season ticket loan
- On-Site nursery
- On-site gym
- Enhanced maternity, paternity and adoption pay
- Employee assistance programme: Staff Support Service
- Discounted medical insurance
For rewards and benefits at UCL please visit: https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits .
As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent.
We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce.
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