Organisation/Company: EMBL-EBI - European Bioinformatics Institute
Research Field: Biological sciences
Biological sciences » Biology, Computer science, Mathematics » Statistics
Researcher Profile: Recognised Researcher (R2)
Country: United Kingdom
Application Deadline: 2 Apr 2025 - 21:59 (UTC)
Type of Contract: Permanent
Job Status: Full-time
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description
Postdoctoral Fellow - Ewald Group
EMBL-EBI - European Bioinformatics Institute
Hinxton, United Kingdom
Your role
The Ewald Lab at EMBL-EBI is seeking a postdoctoral researcher to analyse a first-of-its-kind toxicology dataset. As members of the OASIS Consortium, which brings together 40 pharmaceutical/agrochemical companies, government agencies, academic labs, and non-profit organizations, we aim to develop novel approaches for predicting liver toxicity to reduce reliance on animal testing and increase the accuracy of safety assessment. The dataset includes high-dimensional readouts including Cell Painting, transcriptomics, and proteomics.
Possible directions within this project include:
1. Developing predictive models for compound mode-of-action using multi-omics data;
2. Using deep learning to extract features from:
o Public histopathology images and comparing them to OASIS-generated data;
o OASIS-generated Cell Painting data and using them to investigate single-cell heterogeneity in compound-induced perturbations.
3. Investigating different mathematical approaches to extrapolate biological responses across in vitro and in vivo toxicity tests.
You have
* A PhD or equivalent qualification in computer science, statistics, mathematics, physics, and/or engineering, or a degree in biological science with demonstrated computational experience;
* Strong programming skills, preferably in Python or R;
* Expertise in statistical methods, mathematical modelling, and/or machine learning;
* Proven ability to develop computational methods with applications in biology, preferably for high-dimensional data;
* Demonstrated ability to publish research in international peer-reviewed journals;
* Excellent communication, collaboration, and leadership skills;
* The desire to be a supportive, creative, and responsible team member.
You may also have
* Expertise in computational toxicology or pharmacology, from either a pharmaceutical or regulatory perspective;
* Experience with computational image analysis or multi-omics integration;
* Experience with frameworks like PyTorch, Keras, Pyro, or TensorFlow.
Contract length: 2 years (possibility for extension)
Salary: Year 1 Stipend at rate of £3,307 per month after tax but excluding pension and insurance contributions.
The EMBL Fellows’ Career Service provides support and guidance to predoctoral and postdoctoral fellows across all six EMBL’s sites.
Working with a dedicated Careers Advisor, this invaluable service will help you to take informed decisions about your career planning both in the short and longer term. Whether your main interest is pursuing a career path in academia, exploring opportunities in industry, or exploring an independent venture, the EMBL Fellows’ Career Service will provide you with a portfolio of activities and resources to help you.
We are located on the Wellcome Genome Campus, alongside other prominent research and biotech organisations, and surrounded by beautiful Cambridgeshire countryside. This is a highly collaborative and inclusive community where our employees enjoy a relaxed atmosphere. We are committed to ensuring our employees feel valued, supported, and empowered to reach their professional potential.
* Financial incentives: Monthly family and child allowances, generous stipend reviewed yearly, pension scheme, death benefit and unemployment insurances;
* Flexible working arrangements: including hybrid working patterns;
* Private medical insurance: for you and your immediate family;
* Generous time off: 30 days annual leave per year in addition to public holidays;
* Campus life: Free shuttle bus to and from work, on-site library, subsidised on-site gym and cafeteria, casual dress code, extensive sports and social club activities (on campus and remotely);
* Family benefits: On-site nursery (Heidelberg & Hinxton), 10 days of child sick leave, paid maternity & parental leave, holiday clubs on campus and monthly family and child allowances;
* Benefits for non-residents: Visa and financial support to relocate if you're overseas.
What else you need to know
* International applicants: We recruit internationally and successful candidates are offered visa exemptions. Read more on our page for international applicants;
* Diversity and inclusion: At EMBL, we strongly believe that inclusive and diverse teams benefit from higher levels of innovation and creative thought. We encourage applications from women, LGBTQ+ & individuals from all nationalities;
* Job location: All our fellowships are based on-site (for at least part of each week). If you are living overseas, you will receive a generous relocation package to support you;
* EMBL is a signatory of DORA: Find out how we apply DORA principles to our recruitment and performance assessment processes here;
* How to apply: To apply please submit a cover letter and a CV through our online system. We aim to provide a response within two weeks after the closing date below.
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