Senior Laboratory Research Scientist
Salary for this Role:
From £39,950 per annum with benefits, subject to skills and experience.
Job Title: Senior Laboratory Research Scientist
Reports to: Katrin Rittinger
Closing Date: 10/Nov/2024 23.59 GMT
Job Description:
Job title: Senior Laboratory Research Scientist
Reporting to: Katrin Rittinger, Principal Group Leader
Contract term: This is a full-time, fixed term (24 months) position on Crick terms and conditions of employment.
Project summary:
We are looking for an enthusiastic and proactive scientist to work with us within our EPSRC-funded Prosperity Partnership collaboration between the Francis Crick Institute and GSK. In this collaboration, we are employing covalent fragment screening to simultaneously identify potential new drug targets and small molecule tools.
We have already established a high-throughput chemoproteomic platform that enables covalent fragment screening in cells and have identified many novel protein-small molecule interactions which we now want to explore and develop into high-quality molecular probes. We are now looking for a Senior Laboratory Research Scientist to join our multi-disciplinary team and work on the biochemical and structural characterisation of these newly identified protein-compound interactions to support the rapid generation of tool molecules for disease-relevant protein targets.
The Role:
The role will focus on work within the EPSRC-funded Crick-GSK Prosperity Partnership collaboration.
Key responsibilities:
* Production of recombinant proteins and subsequent biochemical and structural characterisation of protein-compound complexes.
* Establishing biochemical and biophysical assays to study the effect of compound engagement on enzymatic activities or protein-protein interactions.
* Working closely with chemists to explore structure-activity relationships.
* Collaborating with other lab members on research projects.
* Participating and presenting in group meetings, seminars, and scientific meetings.
* Writing up findings for publication.
Experience and Competencies:
The post holder should embody and demonstrate our core Crick values: Bold; Open; Collegial.
Essential:
* PhD or M.Sc. in biochemistry or related discipline.
* Broad experience in recombinant protein production.
* Experience in the use of biophysical techniques to study protein-protein and protein-ligand interactions.
* Excellent technical and problem-solving skills.
* Excellent organisational and time-management skills.
* Self-motivated with the ability to work both independently and as part of a team.
* Strong communication skills to work with diverse scientists across the Prosperity Partnership.
Desirable:
* Experience in the use of eukaryotic systems for recombinant protein expression.
* Experience in cell culture.
* Experience in X-ray crystallography.
* Experience in computational tools to assess protein structure, protein interactions, and other properties.
About Us:
At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas, and resources.
We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.
If you are interested in applying for this role, please apply via our website.
All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
If you require a visa to work in the UK, we will help support your application should you be successful.
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits.
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity.
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