Agenda are looking for a driven in vivo Scientist to spearhead the creation of advanced transgenic avian models for biologic discovery in one of our facilities in Cambridge. This role entails hands-on work with live animals, focusing on the derivation, cultivation, manipulation, and microinjection of primordial germ cells (PGCs), alongside the care and management of transgenic birds. The ideal candidate will collaborate closely with a multidisciplinary team of molecular biologists and discovery specialists, leveraging their expertise to drive forward this impactful project in collaboration with a prominent pharmaceutical company.
Responsibilities
* Isolate, culture, and manipulate primordial germ cells (PGC) for genetic modifications.
* Transfect PGCs with targeting vectors and DNA editing reagents.
* Isolate monoclonal cell lines and ensure their characterization for downstream applications.
* Perform microinjections to introduce modified PGCs into recipient embryos with precision.
* Collaborate on genetic modification strategies like CRISPR/Cas9 and homologous recombination.
* Manage transgenic colonies and implement breeding strategies for maintenance.
* Work with cross-functional teams to design tailored transgenic strategies for biologic discovery.
* Ensure compliance with UK government regulations for animal welfare and biosafety, including obtaining necessary permits for research and transport.
Qualifications
* A Ph.D. or Master’s deg...