About the Company
HotHouse Therapeutics is a first mover company revolutionising natural product drug discovery. We discover the tools which plants have evolved to synthesise bioactive small molecules and then redeploy them to synthesise new-to-nature small molecule drugs. This is an exciting opportunity to join our growing and ambitious team as a bioinformatician and work in a completely new and emerging area of science and drug
discovery. The ideal candidate will have a strong bioinformatics background with experience or interest in applying machine learning to solve biological problems. They will work closely with our Head of Informatics and laboratory-based scientists to continue to develop our platform and deliver innovation.
Responsibilities
• Develop and maintain pipelines for processing and analysing ‘omics data
• Build and maintain knowledge graphs for capturing internal and external bioinformatics data
• Train, validate and deploy machine learning models
• Collaborate with the wider scientific team to deliver projects
Essential requirements for the ideal candidate
• PhD in Bioinformatics, Genetics, Biology, or a related field
• Proficient in Python and/or R
• Experience building pipelines for ‘omics data (e.g. RNAseq)
• Experience with storing, searching and filtering large scale ‘omics data
• Strong problem-solving skills
• Ability to work independently and develop ideas
• Ability to work in a multidisciplinary team
Desirable capabilities in the ideal candidate
• Experience using machine learning packages (e.g. pytorch, tensorflow, scikit-
learn)
• Experience working with metabolomic data
• Familiarity with Git and version control systems
• Familiarity with cloud infrastructure (e.g. AWS)