About the Company
HotHouse Therapeutics is a first mover company revolutionising natural product drug discovery. We discover the biosynthetic tools which plants have evolved to synthesise bioactive chemicals and then redeploy them to synthesise new-to-nature small molecule drugs. This is an exciting opportunity to join our growing and ambitious team as a natural product biologist and work in a completely new and emerging area of science and drug discovery. The ideal candidate will have experience working at the interface of biology and chemistry in a multi-disciplinary environment. They will work with other laboratory-based scientists and informaticians, and be responsible for driving projects forward.
Responsibilities
* Plant tissue culture
* Cloning and transformation in bacterial systems
* Reconstituting and manipulating biosynthetic pathways in heterologous systems
* Extracting and analysing natural products from plant material
* Analysing LC-MS based results to validate and improve pathway efficiencies
* Collaborating with the wider scientific team to deliver projects
Essential
* PhD in Biology, Biochemistry or a related field, or 3+ years experience in a directly comparable field of R&D
* Experience in tissue culture techniques (ideally plant TC, but specific training available)
* Experience using LC-MS based systems and interpreting results
* Experience with molecular biology techniques
* Excellent presentation and communication skills
* Strong problem-solving skills
* Ability to work independently and develop ideas
* Ability to work in a multidisciplinary team
Desirable
* Use of NMR for structure and purity analysis
* Familiarity with natural product chemistry
* Experience using transient plant expression systems
* Knowledge of plant biology