Job Description
We’re Hiring: Senior Protein Scientist
London | Full-time | £55,000 – £65,000 + stock options | Early-stage biotech
Are you passionate about cutting-edge reprogramming protein science and ready to make a big impact? We’re looking for a Senior Protein Scientist to lead our recombinant protein expression program as part of our molecular biology team. If you’ve tackled a range of protein expression challenges—and have the first-author publications to prove it—we’d love to hear from you.
You’ll be a key contributor to our discovery efforts and central to understanding and engineering our newly identified reprogramming factors. This is a high-impact role with scope to shape strategy and build capabilities in a fast-moving and well-resourced biotech environment.
About Us
We’re a VC-backed biotech spun out of a Nobel lab at the University of Cambridge, focused on using epigenetic reprogramming to rejuvenate immune cells. Our mission is to restore function in HSCs and T cells for therapeutic applications in transplantation and cancer immunotherapy. Our platform is built around a novel and powerful reprogramming mechanism that we believe could redefine what’s possible in longevity science.
What You’ll Do
• Lead recombinant expression projects across unusual proteins in mammalian and bacterial systems
• Design and troubleshoot protein constructs, purification pipelines, and characterisation workflows
• Purify proteins using His-tag, SEC (AKTA), and other systems
• Optimise expression for a variety of protein types (secreted, cytoplasmic, nuclear, etc.)
• Drive protein engineering and screening strategies to enhance function
• Contribute to strategic decisions on expression platforms and discovery pipeline acceleration
• Work closely with a cross-functional team of 12 scientists in a collaborative, ideas-first culture
We’re Looking For
• PhD (or equivalent experience) in protein biochemistry, molecular biology, synthetic biology, or related
• First-author publication in a high-impact journal in protein science or molecular biology
• Real-world experience in recombinant protein expression and purification across diverse systems
• Familiarity with construct design, molecular cloning (Golden Gate, Gibson, etc.), and troubleshooting
• Ability to manage complex, multi-step expression workflows with attention to detail
• Comfortable expressing and optimising a range of protein types and characteristics
• Strong communication and collaboration skills—team-first mindset with scientific independence
• Intellectually curious, proactive, and driven to solve hard biological problems
Bonus Skills
• Protein engineering or structural modelling
• Experience with stem cells or cellular reprogramming
• Lentiviral or transposon-based delivery
• Familiarity with qPCR, NGS prep, and data-driven workflows
• Use of electronic lab notebooks (ELNs) and modern lab management tools
What We Offer
• Competitive salary: £55,000–£65,000, based on experience
• Equity options in a rapidly growing biotech
• 28 days holiday + public holidays
• Private healthcare
• Company-matched pension
• A voice in an early-stage team where your work will shape the science
• A mission-driven culture with scientific excellence, creativity, and integrity at its core
How to Apply
If this sounds like you, get in touch—we’d love to share more about the science and hear about your experience.
We welcome applicants from all backgrounds and encourage candidates who are early in their careers but have demonstrated excellence to apply. Your impact matters more than your years in industry.
#J-18808-Ljbffr