Key Information
Salary: Subject to comparable skills and experience. Future progression is based on annual performance review.
This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.
Duration of Contract: Fixed Term for 3 years in the first instance.
Hours per week: 35 hours per week (Full Time).
Closing Date: Sunday 1st December 2024.
First Round Interview Dates: 10th December 2024.
Job Details
Under the leadership of Dr Syed Haider, we are seeking to appoint an Analytical Scientist to join our Breast Cancer Research Data Science Team.
We are seeking a highly motivated bioinformatics researcher to apply and develop computational approaches for investigating subclonal architecture and plasticity in treatment-resistant breast cancers. The successful candidate will employ computational approaches to meaningfully integrate single-cell assays encompassing RNA, T/B cell repertoire, and spatial genomics in order to identify mechanisms of treatment resistance and therapeutic candidates. Beyond computational discovery, suitable therapeutic targets will be subject to pre-clinical investigation and subsequent design of translational studies at our research centre.
Your work will focus on datasets generated using state-of-the-art molecular profiling such as single-cell sequencing and spatial genomic profiling on patient samples throughout disease progression to understand the molecular evolution of breast cancer and response to targeted therapies. Together with wet-lab colleagues, we will investigate molecular barcoding strategies in patient-derived models, mechanistic hypotheses in vitro and in vivo, and candidate biomarkers that inform the design of proof-of-concept clinical trials or drug discovery programmes. In addition, you will be responsible for the analysis and interpretation of high-throughput perturbation screens (where available) for matched single-cell and spatial datasets.
The project offers experience in data science such as statistical modelling and single-cell multi-omics, while investigating novel molecular biomarkers of aggressive breast cancers. The successful candidate will also have opportunities to optimise/extend our existing computational pipelines for pre-processing of big data in breast cancer (genomics, single-cell, and spatial technologies). Given the multidisciplinary nature of this position, the successful candidate is expected to play a key role in liaising with wet-lab scientists, as well as write up research results in a highly collaborative environment.
Key Requirements
Applicants should hold an MSc in a computational/numerical subject, have programming and scripting experience, and possess basic knowledge of biology. A background in the analysis and interpretation of single-cell assays would be highly valuable. A PhD in a computational/numerical subject would be desirable.
Department/Directorate Information
The Breast Cancer Research Data Science Team is an interdisciplinary group of researchers (~12) who are experts in high-throughput data analyses, machine learning, and software engineering. We work in a highly dynamic and collaborative environment focusing on the identification of molecular markers of breast cancer by interrogating genomic, epigenomic, and transcriptomic datasets profiled using bulk as well as single-cell assays.
The Breast Cancer Now Toby Robins Research Centre at the ICR is the first centre in the UK entirely devoted to breast cancer research. Our goal is to advance research into the causes, diagnosis, and treatment of breast cancer.
We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Syed.Haider@icr.ac.uk.
About The Institute of Cancer Research
Why work for us?
As a member of staff, you'll have exclusive access to a range of staff benefits.
The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.
The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.
At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.
Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.
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