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Senior Scientist – Mechanistic Pharmacology, Babraham
Client: Cancer Research UK
Location: Babraham, United Kingdom
Job Category: Other
EU work permit required: Yes
Job Reference: 2bf2a1337011
Job Views: 80
Posted: 18.02.2025
Expiry Date: 04.04.2025
Job Description:
At Cancer Research UK, we exist to beat cancer.
Cancer Research UK's Drug Discovery team is looking for an experienced and passionate Senior Scientist to bring scientific excellence and expertise to the design, prosecution, and analysis of biochemical assays, including bespoke mechanistic data and High Throughput Screening activities.
This is an opportunity for an experienced Senior Scientist to take on a leading role through drug discovery and capability build projects, working closely with academic PIs and Alliance partners. This could be your chance to contribute to defining our future HTS strategy and to validate and embed processes using our new automated robotics screening system. The Mechanistic Pharmacology team is a multidisciplinary group comprising biochemists, enzymologists, biophysicists, cell pharmacologists, sample management, and HTS specialists, providing ample opportunity for learning, cross-training, and development. Furthermore, we actively encourage our colleagues to celebrate our science by attending conferences, presenting posters, giving talks at events, and publishing papers. You’ll also be surrounded by people as dedicated to beating cancer as you.
About CRUK Drug Discovery
As the world’s biggest medical research charity, we have helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.
We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK’s established drug discovery teams under one organization and leadership team, combining our unique pipeline of world-class biology, cutting-edge technology platforms, and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.
What will I be doing?
Our new strategy sets out to bring deeper mechanistic understanding at the molecular and cellular level to all stages of projects, from Idea to pre-clinical candidate.
This laboratory-based role focuses on designing and developing physiologically relevant biochemical assays in 384 well and 1536 well plate format to characterize cancer targets in detail at the molecular level, enable high-throughput screening, profile the structure-activity and structure-kinetic relationships of small molecules, and characterize their mechanism of action to inform dose prediction and clinical efficacy.
The successful candidate will drive innovative ways of working by keeping abreast of cutting-edge biochemistry, enzymology, and HTS science. They will form an integral part of the Cancer Research Horizon Drug Discovery team, working alongside our industry and academic partners to progress novel cancer targets towards patient benefit.
What skills will I need?
1. A BSc, MSc, or PhD in biological science such as biochemistry or pharmacology; relevant experience may be substituted for education.
2. Significant experience in a drug discovery environment of assay development, including dissecting enzyme and small molecule inhibitor mechanisms for a range of target classes.
3. Detailed theoretical and practical understanding of biochemical assays and detection technologies, with a particular focus on physiologically relevant systems.
4. Significant experience in liquid handling and automated dispensing.
5. Significant experience of analyzing large datasets with appropriate statistical rigor.
6. Experience of running biochemical and cell-based high throughput screens of small molecules in 384 well and 1536 well plate format is desirable.
7. Additional experience in prosecution and robust statistical analysis of high throughput screening data would be desirable.
What will I gain?
Our organization values are designed to guide all that we do:
1. Bold: Act with ambition, courage, and determination.
2. Credible: Act with rigor and professionalism.
3. Human: Act to have a positive impact on people.
4. Together: Act inclusively and collaboratively.
We’re looking for people who can believe in and embody these organization values and can use them to drive forward progress against our mission to beat cancer.
If you’re interested in applying and excited about working with us but are unsure if you have the right skills and experience, we’d still love to hear from you.
How do I apply?
We operate an anonymized shortlisting process in our commitment to equality, diversity, and inclusion. CVs are required for all applications; but we won’t be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.
One of our values at CRUK is Being Human. Whilst we understand that AI has its benefits, we want to hear about your personal experiences and why these make you suitable for the role. We have noticed some applicants being less successful in their applications when using AI due to lack of real-life examples. To level the playing field and ensure fairness for all candidates, we strongly encourage responses to be written in your own words, drawing from personal experiences and knowledge. We discourage the use of AI when completing your application form and throughout the process.
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