This role is based either in the East Coast of the USA (remote) or in our Paddington office in the UK (office based) Job De scription Director, Nonclinical Development Our Destination “Computing the future of medicine” We are integrating the latest advances in computing and artificial intelligence to develop life-transforming RNA interference (RNAi) medicines. We combine cutting-edge computation and AI with RNAi to make better medicines faster. Our unique approach enables us to differentiate, de-risk, and rapidly deploy our enabling platforms (HepNet™ and GalOmic™) and therapies, improving upon traditional approaches to drug discovery. Our rapid and reproducible process has produced a broad therapeutic pipeline of multiple GalOmic™ RNAi therapies targeting novel genes that have demonstrated disease-modifying potential in preclinical disease models. We are advancing our pipeline towards the clinic, with our most advanced asset (ETX-312, for the treatment of MASH) currently undergoing IND-enabling studies, the final stage of preclinical development. It is an incredibly exciting time for ETX, as we get closer to delivering on our mission of delivering life-transforming medicines to patients and ultimately realising the full potential of our AI-enhanced approach to drug discovery. Our Journey Great progress demands great people. We aim to make the impossible, possible with a healthy dose of fun along the way. We prize creative thinkers who like to join the dots and love to recognise those that do. Everyone has potential; here, you will be able to fully realise it. In joining us, you're not just joining a company, you're taking a chance to pioneering change and shifting the paradigm in biotech. Our dynamic environment and team will empower you to take initiative, explore new ideas, and drive groundbreaking results. Your Adventure This position offers an amazing opportunity to provide leadership for the growing Nonclinical Development team at ETX. Reporting into the VP, Head of Early-stage Development, this role will be instrumental in driving our organization’s nonclinical strategy and overseeing the execution of non-clinical programs to advance our pipeline of innovative RNAi medicines. What you will do Oversee non-clinical study strategy, design, and execution for the ETX pipeline including experimental approach, data packages, and regulatory content preparation to advance our development candidates Assume responsibility for delivering high-quality data packages to regulatory authorities, supporting clinical development Work with cross-functional project teams for design and execution of non-clinical development strategy Establish and maintain effective relationships with CROs and consultants for the design and execution of nonclinical studies to guarantee readiness of development candidates for regulatory submissions and clinical development Provide leadership for nonclinical project manager and ensure all nonclinical programs are completed within established timelines Responsible for preparation and presentation of nonclinical project updates to the Executive Team Collaborate closely with finance and operations teams Author, review and approve scientific reports that support regulatory documents including INDs, CTAs, and NDA filings Develop contingency plans and backup scenarios to proactively mitigate unforeseen circumstances and minimize potential impact on timelines Skills & qualifications Essential: A PhD in pharmacokinetics, biology, pharmacology or a related discipline, with a deep insight into drug metabolism, ADME concepts, pharmacokinetics, and bioanalytical principles 10 years’ drug discovery experience in pharma and/or biotech with a track record of nonclinical development Extensive experience of nonclinical study design and execution leading to regulatory submissions. Strong knowledge of global regulatory requirements, including FDA, EMA, MHRA, and other major regulatory authorities, with prior experience supporting regulatory submissions Knowledge of the CRO landscape and experience working with nonclinical CROs to deliver fully costed agreements and study protocols, while building strong relationships with partners A commitment to generating data of the highest integrity, complying with regulatory requirements and ethical standards Project management, organisational and leadership skills and experience are highly valued A sense of drive and urgency to achieve the project goals Ability to form strong working relationships that enable the leveraging of multidisciplinary expertise to deliver projects Excellent communication skills in verbal and written English, with the ability to prepare clearly articulated scientific reports supporting regulatory documents such as INDs Nice to have: A background in therapeutic siRNA or other oligonucleotide therapeutics Our culture & values Our success starts & ends with our team – the passionate, curious and collaborative individuals who work here. All are committed to pushing technology to the limit to make a difference to patients, to R&D and to each other – we call this our PACT. We’re not looking for people who are exactly like us. We’re looking for people who care about and value the same guiding principles while bringing different ideas, perspectives & opinions. Our benefits We invest in your success Competitive salary Discretionary performance related bonus PACT awards (monthly recognition scheme) If USA based We care about you Private medical cover with United Healthcare Dental plan with Delta Dental Vision plan with VSP Vision Care We help you protect your future 2% contribution to 401(k) up to maximum of $6,900/annum with 3% salary enhancement to help you increase your retirement plan contributions Life insurance (2 x annual salary up to maximum $400,000) We unlock your potential Personal development time Departmental learning and development budget (including attending external training, conferences, etc.) We make it fun Bi-annual social event 22 days PTO 11 US public holidays If UK based We care about you Private medical cover with Bupa Medicash Health Cash Plan Employee Assistance Programme Reward Gateway (deals & discounts and wellbeing centre) Annual season ticket loan We help you protect your future 10% employer pension contribution (you can also make your own contributions via salary sacrifice) Life insurance (4 x annual salary) We unlock your potential Personal development time Departmental learning and development budget (including attending external training, conferences, etc.) We make it fun Social and well-being events throughout the year such as a newly created ETX Summer dodgeball team, bouldering, pizza making sessions and we even have a basketball court on our roof terrace 25 days of annual leave public holidays EDI Statement Our ambition is to have a positive impact on society at a global level by discovering and developing novel therapeutic targets in areas of high unmet need. We believe that providing equal opportunities, valuing diversity, and promoting a culture of openness and inclusivity are vital in the journey to realise our ambition. We therefore aim to create an environment where people are free to be themselves regardless of their identity or background.