Direct message the job poster from TRIMTECH Therapeutics Limited
Developing therapies for neurodegenerative diseases
TRIMTECH therapeutics is a vibrant, seed-stage biotech company founded on the pioneering work of Dr. Leo James and Professor William McEwan (Science, 2024 and Cell, 2024). Our mission is to create novel small molecule degraders of protein aggregates to cure neurodegenerative diseases. TRIMTECH Therapeutics has recently raised $31 million in an oversubscribed seed financing round and is now expanding its team.
We are seeking a highly skilled and enthusiastic medicinal chemist to support our drug discovery efforts. The role is office based (at least 3 days a week) and requires working closely with our internal chemistry and biology teams, third party CROs, to design and oversee the synthesis and biological characterisation of our small molecule degraders. You will:
* Play a key role in the medicinal chemistry team, helping to build a vibrant R&D group
* Implement modern techniques to drive drug design, positively impacting progression of medicinal chemistry programs
* Collaborate with third party CROs and consultants, solving medicinal and synthetic challenges, to enable timely execution of project activities
* Record and analyse all relevant project data
* Collaborate across-functions in the Design-Make-Test-Analyse cycles
If you are eager to make a significant impact in the field of drug discovery for the treatment of neurodegenerative diseases, you fulfil the key requirements below and you are ready for your next step, we encourage you to apply to join our team at TRIMTECH therapeutics. You will be a key contributor to the development of groundbreaking treatments for neurodegenerative diseases.
Key requirements
* PhD in a chemical science related discipline (or a MSc with subsequent equivalent industry experience), followed by 3 or more years’ experience in a drug discovery environment with a track record of significant achievements
* Demonstrated ability to work creatively to solve medicinal chemistry challenges and synthetic problems
* Excellent communication skills, working collaboratively across disciplines to impact drug discovery programs
* Understanding of target protein degradation as therapeutic modality, with its challenges and opportunities
* A keen interest in maintaining awareness of advances in synthetic chemistry and drug design
* Must be a team player, have a “can do attitude” and be fun to work with
Desirable Skills and Attributes (one or more of these is desirable, but not essential)
* A strong interest in biology and/or chemical biology
* Experience in structure-based drug design and the use of biophysical methods in drug discovery
* Experience with electronic databases such as CDD Vault
* Experience with computational chemistry and data analytics (workflow) platforms
* Experience directing one or more CROs through synthetic challenges to deliver to ambitious project timelines.
* Experience in property-based drug design
To apply please send a cover letter and CV to recruitment@trimtechtherapeutics.com
Seniority level
* Mid-Senior level
Employment type
* Full-time
Job function
* Research, Analyst, and Information Technology
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