Role Description PhoreMost® is looking for a talented and innovative computational chemist to join our Drug Discovery team. The position can be appointed at Senior or Principal Scientist level dependent upon experience. The successful candidate will play a key role in enabling the success of multiple drug discovery programs through computational expertise. The candidate will be required to run the computational chemistry capability within PhoreMost and bring onboard new methodologies to be integrated into the platform. The primary responsibility will be to provide computational chemistry support in the design of high-quality molecular glue and PROTAC molecules that constantly progress closer to the target product profile (potency, selectivity, ADME), in collaboration with medicinal chemists and other interdisciplinary scientists. Also, the role will include supporting the Target Discovery team through experience of protein modelling. The ability to work effectively as part of a multi-disciplinary drug hunting team will be an essential attribute of the successful candidate. About Us We are a biotech company based in state-of-the-art laboratories at Unity Campus, Cambridgeshire, UK. PhoreMost is focussed on developing the next generation of small molecule Targeted Protein Degradation drugs within oncology and inflammatory diseases. We have developed proprietary high-throughput phenotypic screening technologies, SITESEEKER ® and GlueSEEKER™ ( phoremost.com/science ), that exploit protein shape diversity to uncover novel targets within complex biological systems. These platforms are used to identify differentiated E3 ligases to drive degradation of therapeutic targets, and to systematically identify molecular glue degraders against unprecedented targets. Targets arising from these platforms are translated towards patient benefit by our in-house drug discovery team. PhoreMost has developed a number of industry partnerships across diverse therapeutic areas and an exciting pipeline of drug discovery programmes. Our technologies are positioned to unlock the therapeutic potential of Targeted Protein Degradation and to massively expand the diversity of novel therapeutics for several key diseases of unmet clinical need. PhoreMost is proud to be an equal opportunities employer. We are committed to creating an inclusive working environment and we celebrate diversity. Every application will be evaluated based on merit and without discrimination. Roles and Responsibilities Provide computational chemistry support across a portfolio of drug discovery targets from hit identification through to late lead optimization projects in the molecular glue and PROTAC areas Contribute scientific ideas and implementation of new cutting-edge techniques Work collaboratively within the Drug Discovery and Target Discovery groups and across multi-disciplinary teams (potentially including external collaborators) Effective communication and presentation of results to diverse audiences including to internal teams and external partners Additional Principal Scientist responsibilities may include leading early-stage projects (depending on experience) Person Specification Essential PhD or equivalent in computational chemistry with 2 years’ experience in the biopharma industry Appointment at Principal Scientist level will require minimum 5-10 years postdoctoral experience in an industry setting Excellent written and oral communication skills, including the ability to explain computational methods to a multidisciplinary audience Ability to work on multiple programs simultaneously Excited about the prospect of artificial intelligence approaches and their application to drug discovery Experience with computational chemistry methods like virtual screening, MD, QSAR, PK/PD modelling and FEP, MM/GBSA calculations Knowledge and experience of protein structure and protein modelling, and protein complex modelling Experience of using Linux based high performance computing systems Excellent team player, enthusiastic and actively seeking to learn and develop Attention to detail, structured thinking, good communication and time management skills Committed to the pursuit of new therapies for critical unmet clinical need Desired Experience of computational chemistry support for molecular glue and PROTAC discovery Experience with protein-protein interaction inhibitor drug discovery Experience of machine learning frameworks You must be eligible to work in the UK to apply for this role Closing date 22nd November 2024 (interviews will be taking place throughout the application window)