Home Jobs Postdoctoral Research Associate (10359)
Postdoctoral Research Associate (10359)
2nd January 2025
The Rosalind Franklin Institute is a national research centre, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology. In collaboration with the MSD London discovery centre, we are recruiting a Postdoctoral Research Associate within the Structural Biology theme. You will use an integrative structural cell biological approach to dissect the molecular mechanisms underpinning the development of Parkinson’s disease (PD), investigating how proteins involved in mitophagy lead to cellular dysregulation.
You will develop methods for targeting specific neuronal features and characterise the structural and mechanistic changes of the cytoskeleton in stem cell or tissue-derived neurons. The successful candidate will establish a workflow to culture and prepare neuronal cells for integrative imaging using fluorescence microscopy, cryoFIB/SEM, cryoET and sub-volume averaging.
Responsibilities
* Embrace the primary project associated with this role, involving cell culture of primary neuronal cells/tissues, stem cells for differentiation into neuronal cell lines, preparation of samples for cryoET, structure/function analysis of proteins involved in cytoskeletal organisation and the development of methods to visualise and assess the 3D organisations of these proteins in their native cellular context.
* Drive your own research within the scientific scope of the project, including formulating and testing scientific hypotheses, analysing cryoET data produced in-situ, and developing new directions for scientific exploration.
* Design and carry out experiments in collaboration with other researchers within the Franklin, as well as institutions around the UK and globally.
* Contribute to the general development of research and outreach activities within the Franklin organisation, and at the new Franklin hub.
* Publish research findings in leading academic journals.
* Present research findings in UK and worldwide academic conferences.
* Take a formal or informal role in the supervision of research students and other junior lab members.
* Any other duties that come up in the normal running of the facility and that can be reasonably requested of the post-holder.
Minimum Requirements
This post would be ideal for a candidate who has worked, or is willing to drive developments, in eukaryotic and stem cell culture methods and would like to develop skills in structural cell biology and electron cryo-tomography applied to complex systems. Candidates must hold a PhD/DPhil (or equivalent), or be close to completion of their PhD/DPhil qualification.
In return we offer:
* 25 days holidays plus bank holidays and Christmas holiday shutdown
* Generous pension scheme (employer’s contribution currently up to 18%)
* Group Life Assurance (also known as Group Life Insurance or Death in Service)
* Hub building with state-of-the-art laboratories
* Hybrid and flexible working
* Training and development opportunities for staff at all levels
* Bus pass discount scheme and good transport links to Oxford and surrounding areas
* Cycle to Work Scheme
* Access to employee discount platform (Perkbox)
* Occupational Health and wellbeing support including Employee Assistance (24/7 support and counselling)
* Health Cash Plan
* Subsidised canteen and food outlets on campus
* Free on-site parking
* Campus location in beautiful countryside with social and sports clubs open to staff
Closing date: The closing date for applications is 23:59 on Sunday 12th January 2025.
Period of appointment: 3 Years Fixed-Term Contract
Salary: From £37,500 per annum (depending on skills and experience)
#J-18808-Ljbffr