This is a Fixed Term post for 3 years working full-time.
The project will focus on the measurement of DNA damage and DNA mutations in the blood cells of night shift workers compared to the general public. The project will utilise age-matched night shift workers and non-night shift workers to study any role of DNA damaging events linked to night shift working. The study is funded by the Colt Foundation who specialise in occupational exposures and health risks. The study will elucidate the mechanisms behind any elevation in DNA damage in those working night shifts and dose responses (duration and frequency of night shifts). These mechanisms may include the role of oxidative stress, the involvement of melatonin and vitamin D and the impacts of circadian disruption on cell biology. This project will appeal to those with a background in measuring DNA mutations in human volunteers.
Essential criteria for this role include experience of measuring DNA damage in human blood cells and also experience in managing the ethical governance aspects of human studies.