Job Description We have a new opportunity for a Senior Scientist who will join a dynamic and fast-moving team and will be primarily responsible for the design and synthesis of novel Bicycles and conjugates with a goal of delivering clinical candidates. In this role you will be required to manage external resources to deliver on synthetic and analytical tasks and will also work collaboratively with the scientific team in a project team environment to progress Bicycle’s oncology pipeline. You will have demonstrated a high level of proficiency in modern synthetic organic / medicinal chemistry as applied to drug discovery and lead optimization of small molecules and peptides and will be experienced in the application of structure-based design, the use of non-natural amino acids, linkers and novel conjugation chemistries. You will work as part of the Medicinal Chemistry team and will contribute to the chemical optimisation of Bicycle monomers and the design and synthesis of Bicycle oncology agents via external CRO partners. For project centric activities, data and progress review, the role will involve close interaction with the Platform, Biology, DMPK, in-vivo Pharmacology teams. Key responsibilities: Driving chemistry activities within a project team, including the design of bioactive Bicycle® peptides to a set Target Product Profile Serve on internal project teams, communicate with project team and colleagues effectively and work well with others to meet experimental and organizational goals Present the results of independently conducted research effectively in oral or written form to line manager, project team members and management level meetings Coordinate chemistry at external contract research organizations (CROs) including maintaining a good relationship, development of detailed chemistry plans, project tracking, data and compound management, critical evaluation of results and analytical data including NMR, LCMS, HPLC, UV-VIS and troubleshooting synthetic issues Exercising independent judgment in developing methods, techniques and evaluation criteria for obtaining results Prepare reports and contribute to drafting and reviewing patent filings Prepare manuscripts for submission to peer reviewed journals Support the development new innovations which expand the company platform by keeping up to date with relevant scientific literature and engaging with scientific discussion and applications within the research and Innovation department