About ANGLE: ANGLE is a world-leading liquid biopsy company commercialising a patent protected platform technology that can capture rare circulating tumour cells (CTCs) from blood, in a minimally invasive way, for downstream analysis. ANGLE's Parsortix® system is FDA cleared for its intended use in metastatic breast cancer and is currently the first and only FDA cleared medical device to harvest intact circulating cancer cells from blood. Parsortix technology comprises a microfluidic device that captures CTCs from blood based on their size and compressibility. CTCs are cancer cells that have detached from the primary tumour and entered the blood circulation, and they play a critical role in initiating metastasis. Once harvested, the CTCs can be comprehensively analysed to provide a wealth of information about the patient’s tumour, advancing cancer research and potentially personalized medicine. This technology has the potential to deliver profound improvements in clinical and health economic outcomes. ANGLE has established a CTC harvest and analysis service from our UK-based Clinical Laboratory based in Guildford for customers worldwide. In alignment with company priorities, we plan to rapidly expand our services to include molecular profiling of CTCs and ctDNA using digital PCR and NGS to add to our image-based assays. Join our Team: This is an exciting time at ANGLE and our team in Guildford are looking for a Manufacturing Senior Manager, The Senior Manufacturing Manager will oversee the daily operations of the manufacturing department, ensuring products meet high quality, safety, and compliance standards in line with GxP regulations (GMP, GCP, GLP). This role requires a scientific background, a strong understanding of biotech processes, and hands-on experience in a regulated environment. At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading-edge translational research into clinical diagnostics. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas. We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please describe your background and what you can bring to our team along with attaching your resume. Principal Accountabilities: The Senior Manufacturing Manager will play a critical role in scaling operations, improving production efficiency, and maintaining compliance with industry and regulatory standards. Operational Leadership: Oversee day-to-day manufacturing activities, ensuring production goals, quality standards, and timelines are met. Responsible for execution and delivery and resolving any issues with the relevant teams GxP/ISO13485 Compliance: Maintain and enforce GxP (Good Manufacturing Practice, Good Laboratory Practice, Good Clinical Practice) compliance within manufacturing processes. Ensure adherence to FDA, ISO, and other applicable regulations. Team Management: Lead and mentor the manufacturing team, fostering a culture of excellence, accountability, and continuous improvement. Process Improvement: Identify and implement process improvements to optimise production efficiency, reduce costs, and enhance product quality. Cross-Functional Collaboration: Work closely with Quality Assurance, R&D, and Regulatory Affairs teams to ensure manufacturing processes meet required specifications and are aligned with product development goals. Lead Tech Transfer of Products: Develop and deliver transfer plan with R&D to understand and transfer all the technical aspects of the product. Documentation & Reporting: Responsible for creating and writing all manufacturing documentation and ensuring it is accurate, up-to-date, and compliant with regulatory requirements. Key signatory for manufacturing documentation such as MI, WI, BMR and other. Prepare reports for senior leadership, identifying key metrics and areas for improvement. Resource Management: Plan and manage manufacturing resources, including personnel, equipment, and materials, to meet production demands. Risk Management: Identify potential risks within manufacturing processes and implement corrective and preventive actions to mitigate those risks. Budget Control: Responsible for manufacturing budget Any other ad hoc responsibilities as required, such as hands-on manufacturing lab work Deputy for Head, Operations when required Qualifications, Experience, Knowledge and Attributes: Bachelor’s or Master’s degree in a scientific discipline (e.g., Cell Biology, Oncology or Molecular Biology,) is required. Minimum of 8-10 years in a manufacturing role within the biotech, pharmaceutical, or medical device industry, with at least 3-5 years in a management capacity. Experience working to strict quality standards such as Medical Device regulations and standards including, but not limited to, 21 CFR 820, ISO 13485, 93/42/EEC, IVD 98/79 EC, ISO14971. Strong knowledge and experience with GxP regulations, including GMP (Good Manufacturing Practice), GLP (Good Laboratory Practice), and GCP (Good Clinical Practice) within a biotech or medical device environment. A strong understanding of the importance of accurate record keeping within a strictly controlled quality system is essential. Understanding of biotech manufacturing processes and proficiency with manufacturing technologies and software. Proven track record of managing, mentoring, and developing high-performing teams in a regulated manufacturing environment. Strong analytical and problem-solving skills, with a focus on continuous improvement. Clear and effective communication skills for both internal teams and cross-functional collaboration.Written and verbal. Entrepreneurial thinking and work ethic Job Requirements: Due to the nature of the role, our requirement is for this position to be Guildford based, office hours, five days per week. As a member of our highly skilled team you will receive opportunities for training and development and a competitive benefits package. Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs. Furthermore, please be advised that if you submit an application to us for this position, your application and personal details will be processed in accordance with our Data Privacy Notice for Job Candidates. Important notice to Employment Businesses/ Agencies: ANGLE does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact our ANGLE recruitment team to obtain prior written authorisation before referring any candidates. In the absence of such written authorisation being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ANGLE. ANGLE shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.