We arecurrently seeking an experienced protein biochemist with expertisein the expression and purification of a variety of recombinantproteins including integral membrane proteins for use in structuralstudies to join our Protein Expression & PurificationDepartment. The successful candidate will have the opportunity tomake a significant scientific contribution to exciting drugdiscovery projects. As well as a track record of working withmultipass membrane proteins the individual should have an excellentunderstanding of their structure andfunction.
Responsibilities
Take a lead role in the expression and purification of recombinantproteins including multipass membrane proteins for structuralstudies.
A key aspect of this position will be communication both within theprotein group and across multiple disciplines (project teamsenzymologvists crystallographers and CADD groups) ensuring thatinformation on work progress is relayed in a clear mannerhighlighting any technical issues and providing potentialsolutions.
Keep abreast of and implement technology developments within thearea of protein expression and purification especially techniquesinvolved in the production of recombinant proteins includingmultipass membraneproteins.
Requirements
PhD holders or highly experienced Bachelor/MSc degreeholders. Preference will be given to candidates who have spent timeworking within labs recognised for their expertise in the field ofmultipass membrane proteins.
We are looking forcandidates who can demonstrate the following skill sets:
PhDholders or highly experienced Bachelor/MSc degreeholders.
Familiar with insect and mammalian cellexpression systems.
Fully independent in purificationtechniques (affinity chromatography ion exchange SEC andHIC).
Extensive working knowledge of AKTA purificationplatforms and associated software.
Comprehensiveknowledge and experience with software used in manipulating proteinand DNA sequences (VNTI) and molecular visualisation of proteins(PyMOL or similar).
An excellent knowledge of theliterature around the generation of recombinant proteins includingmultipass membrane proteins for structural studies.
In addition all applicants must possess excellentwritten and verbal communicationskills.
We are currently seeking an experienced protein biochemist withexpertise in the expression and purification of a variety ofrecombinant proteins including integral membrane proteins for usein structural studies to join our Protein Expression &Purification Department. The successful candidate will have theopportunity to make a significant scientific contribution toexciting drug discovery projects. As well as a track record ofworking with multi-pass membrane proteins, the individual shouldhave an excellent understanding of their structure andfunction.