About Us
Everyone should have access to innovative therapies that represent the promise of lasting cures. At Theolytics, we are working to transform patients' lives through world-leading science, with a great team (www.theolytics.com).
Theolytics is developing best-in-class oncolytic viral therapies. The company's lead program has entered into the clinic with the ambition of providing better outcomes for patients with ovarian cancer, for whom current treatment options are limited. Additional pipeline programmes in preclinical development include novel oncolytic virus candidates for colorectal cancer and hematological malignancies where there remains significant unmet need.
Theolytics is committed to creating, inspiring and protecting a culture of inclusivity and diversity in everything we do. We bring our authentic selves to work and strive to find and support the best person for any given role within our team. Our recruitment leads with capability, values, and performance.
Opportunity
We are looking for a Principal Scientist to join our multidisciplinary and dynamic team. This position represents an excellent opportunity for someone wanting to contribute to the translation of an early-stage oncolytic immunotherapy product through clinical development.
The successful applicant will be working in a fast-paced environment to design and execute cutting-edge projects and contribute to strategic research and development goals. The candidate must be a proactive, organised individual and possess a range of technical expertise and knowledge in cancer biology, tumour microenvironment, immunology, and in vivo techniques.
We are looking for someone who is a self-starter, has excellent communication skills, can interact with a diverse group of scientific disciplines, and is happy to jump in when required in what is an exciting work environment.
Responsibilities
1. Drives oncolytic immunotherapy candidate development, with particular emphasis on evaluating mechanism of action, influence on the tumour microenvironment, and application in new tumour indications, to inform clinical strategy.
2. Act as Study Director, being responsible for study plan design and approval for studies as well as overseeing data collection, analysis, and reporting. Responsible for making sure the study plans and reports are to the standards of regulatory submission.
3. Mentor and supervisor to team scientists (may include line management responsibility).
4. Prioritisation of workloads and coordination of scientific work streams and processes.
5. Collation and presentation of research findings at internal/external meetings.
6. Act as independent scientist reviewer and sign off lab books, verify the calculations, and approve technical SOPs.
7. Contribution to a range of key strategic documents including reports and presentations, patent applications, and regulatory filings.
We're Looking For Someone That Has
1. PhD degree or equivalent experience in a relevant discipline with strong scientific acumen and deep knowledge of cancer biology and the tumour microenvironment.
2. Experience of multiplex immunofluorescence/RNAscope/spatial transcriptomics/IHC/flow cytometry/Prime Flow.
3. Experience in handling and processing primary tissue samples, and advanced cell culture experience.
4. A significant level of hands-on experience in performing in vivo experiments in oncology models for drug discovery, preferably humanised immune mouse models.
5. Experience performing i.t./i.v/i.p injections and establishing tumour models.
6. Builds networks with other teams and external specialists.
7. Strong team player who enjoys working in a highly collaborative environment and is adaptable to evolving business needs.
8. Evidence of impactful research experience through publications, patents, and/or presentations at national/international conferences.
9. Ability to work independently in an organised and methodical fashion.
10. Strong IT skills (including proficiency with Word, Excel, and PowerPoint), and comfort using shared drives.
11. High motivation for, and commitment to, research on anticancer therapies and drug discovery.
It Would Be Useful If You Have
1. Active animal licence from the Home Office.
2. Experience of live tissue slicing and culture/tissue dissociation.
3. Experience of single cell RNA sequencing and bioinformatic analysis.
4. Experience of in vivo imaging (e.g. bioluminescence).
5. Experience working with oncolytic viruses and/or adenoviruses.
6. Technical experience on qPCR, RNA/DNA extractions, ELISA, and cell-based assays.
7. Initiative, and a willingness and propensity to take on responsibility.
8. A collaborative attitude with a flair for problem-solving.
Company Benefits
Competitive salary and holiday allowance, flexible working hours, private medical insurance, company socials, ongoing training and workshops, and an employer-matched pension scheme.
Come Work With Us
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