Research Technician in Bioconjugation and Mass Spectrometry
We are seeking an ambitious and creative Research Technician to join the group of Prof Ed Tate at Imperial College to support our teams working on antibody-drug conjugates (ADCs) and small molecule drug discovery through high-throughput intact protein mass spectrometry.
Bioconjugation of payloads to antibodies and other biological delivery vehicles offers a unique mechanism for the targeted delivery of cytotoxic molecules selectively to diseased tissue, vastly expanding the variety of payloads which can be used in the treatments of disease. In the Tate group we work on all aspects of bioconjugate development with projects spanning payload diversification, discovery and delivery vehicle optimisation/expansion. This is a rapidly evolving field, and ADC-related spinouts from our lab have raised over $100 million in Venture investment to date (e.g. Myricx Bio, myricxbio.com). We also undertake targeted covalent drug discovery, using high-throughput intact protein LC-MS as a key screening assay platform.
What you would be doing
Your role will be to support a diverse project portfolio through design and execution of bioconjugation experiments from initial conjugation, through reaction monitoring and analysis and purification of synthesised conjugates. This role will have a focus on the use of intact protein Mass Spectrometry (MS) at our state-of-the-art Agilent Measurement Suite (Agilent Measurement Suite) and you would also support projects using high-throughput MS screening to identify compounds which can covalently label proteins, using state of the art equipment including the Agilent RapidFire platform.
You will be an enthusiastic and capable individual with prior relevant experience gained within industry or an academic environment. You will support the Tate group working across a variety of chemical biology and drug discovery projects, with a specific focus on bioconjugations and protein mass spectrometry. You may also be involved in collaborations with biopharma companies in the ADC and covalent ligand discovery space, for example our spinout company Siftr Bio (Siftr Bio).
What we are looking for
Essential criteria for the role include:
* A minimum of a BSc qualification in chemistry, chemical biology, biochemistry, or a closely related field, or an equivalent level of professional qualifications and experience.
* Experience in running bioconjugations and the use of related analytical Mass Spectrometry methods.
Desirable experience for this role includes one or more of the following: A Master’s degree in a related field; experience with relevant laboratory management; experience with intact protein Mass Spectrometry sample preparation / analysis; experience carrying out plate-based assays.
Further information
The position is available full time, starting in June 2025 (or as soon as possible thereafter).
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above.
We reserve the right to close the advert prior to the closing date stated should we receive a high volume of applications. It is therefore advisable that you submit your application as early as possible to avoid disappointment.
About Imperial
Welcome to Imperial, a global top ten university where scientific imagination leads to world-changing impact.
Join us and be part of something bigger. From global health to climate change, AI to business leadership, here at Imperial we navigate some of the world’s toughest challenges. Whatever your role, your contribution will have a lasting impact.
This is your chance to help shape the future. We hope you’ll join us at Imperial College London.
Our Culture
We work towards equality of opportunity, to eliminating discrimination, and to creating an inclusive working environment for all. We encourage applications from all backgrounds, communities and industries, and are committed to employing a team that has diverse skills, experiences and abilities.
Our values are at the root of everything we do and everyone in our community is expected to demonstrate respect, collaboration, excellence, integrity, and innovation.
#J-18808-Ljbffr