Site Name: Cambridge 300 Technology Square
Posted Date: Mar 6 2025
The Intracellular Targeted Cancer Therapeutics (ITCT) Biology Unit within the Oncology Research Unit is seeking an experienced Cancer Biologist for an Investigator role that will support a growing portfolio of precision oncology assets. The successful candidate will have a strong background in cancer biology with experience designing and executing biological studies to understand the mechanism-of-action of small molecule cancer therapeutics.
Responsibilities:
* Work within a dynamic and global matrix team environment providing basic and translational biology support for target validation, drug discovery, and early clinical development of novel small molecule cancer therapies.
* Work independently to design, execute, and oversee impactful in vitro experiments informing the development of portfolio assets.
* Champion innovative experimental techniques or technologies, including medium-throughput scalable assay development, target-specific mechanistic biology, and monotherapy and combination anti-cancer efficacy of assets.
* Build communication networks across the Oncology Research Team and broader organization.
* Guide the maturation and de-risking of novel therapeutic concepts.
Basic Qualifications:
* PhD in Cell Biology, Molecular Biology, Cancer Biology, Pharmacology, or related life sciences field with 3+ years of pharmaceutical or biotechnology industry experience in small molecule/cancer intrinsic drug discovery.
* MS in Cell Biology, Molecular Biology, Cancer Biology, Pharmacology, or related life sciences field with 6+ years of pharmaceutical or biotechnology industry experience in small molecule/cancer intrinsic drug discovery.
* Experience leading design, execution, and data analysis for Small Molecule/Cancer Intrinsic experiments including, Target Identification and Validation, Assay Development, and Critical Path Mechanistic and Translational Biology of Targeted Cancer/Oncology Therapies.
* Record of peer-reviewed publications, presentations, and/or patents.
Preferred Qualifications:
* Experience identifying and validating novel small molecule targeted therapeutics.
* Experience with the design and functional testing of diverse small molecules.
* Experience in the design and execution of drug combination screens and the utilization of screen data for drug discovery and development.
* Experience in the design and implementation of functional genomic and/or chemogenomic screens and their application to drug discovery and target identification.
* Experience supporting the delivery of small molecule assets to the clinic.
* Deep knowledge in tumor intrinsic mechanisms, resistance to cancer therapies, DNA damage response (DDR), genome instability, and replication stress.
* Working knowledge of -omic methods (e.g., sequencing, transcriptomics, and/or proteomics) and databases (e.g., Sanger, DepMap, CCLE, etc).
* Expertise in imaging-based assays and analysis.
* Excellent written and verbal communication skills with a strong background in cancer biology.
* Attention to detail and proficient reasoning skills in experimental design, data analysis, statistical methods, and interpretation.
* Independence, problem-solving abilities, self-motivation, resourcefulness, and organizational, interpersonal, and communication skills.
* Ability to work efficiently in a fast-paced team environment and to manage multiple priorities in a matrix environment.
The position is available in Cambridge, MA, USA.
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