Requisition ID: 27937
Location: Newcastle, GB
Contract Type: Fixed Term
Working Pattern: Full Time
Posted Date: 27 Feb 2025
Closing Date: 20 March 2025
Salary:
Research Assistant: £32,546 to £34,132 per annum
Research Associate: £35,116 to £38,249 per annum
The Role
We have an exciting opportunity for a Research Assistant/Associate to join a leukaemia research team within the Biosciences Institute. You will work within the Wolfson Childhood Cancer Research Centre to support a new project funded by Cancer Research UK.
You will work independently to characterize the role of strong regulatory regions, called super-enhancers, in driving aberrant gene expression in childhood acute lymphoblastic leukaemia. This involves applying sophisticated gene editing techniques such as CRISPRi along with CUT&Tag and ATAC-seq experiments for functional analysis of in vitro models. You will collaborate with other members of the group leading to the discovery of new knowledge.
This post is fixed term for a period of 3 years (from a start date of 1 April 2025).
To apply, please submit your CV and a personal statement outlining your suitability for the role using evidence to highlight how you meet the essential criteria in the knowledge, skills, and experience listed in the job description.
Key Accountabilities
1. Contribute ideas, including enhancements to the technical or methodological aspects of studies.
2. Develop and carry out the specified project using appropriate techniques and equipment.
3. Determine appropriate methodologies for research, with advice and support as needed.
4. Contribute to grant applications and develop own research objectives and proposals.
5. Write proposals for individual research funding or contribute to collective bids.
6. Assess research findings for further investigations.
7. Contribute to the writing up of research for publication and dissemination.
8. Present research findings at conferences or through publications.
9. May supervise final year undergraduate research projects and provide support to postgraduate research students.
10. Interact with support staff, undergraduate and postgraduate students, and academic members of the Institute.
11. May contribute to public engagement events.
12. Develop an awareness of University structures, policies, and relevant issues in higher education and research.
The Person
Knowledge, Skills and Experience
1. Ability to work well as part of a team and rapidly acquire new skills.
2. Detailed subject knowledge in leukaemia, chromosomal rearrangements, and epigenomics.
3. Advanced skills relevant to the research project.
4. High level of analytical and problem-solving capability.
5. Ability to communicate complex information clearly.
6. Experience of research with transferable skills and awareness of the research environment.
7. Presentations at conferences and/or high-quality publications.
8. Extensive experience and understanding of cell culture techniques.
9. Experience in genetic engineering techniques including cloning and lentiviral particle formation.
10. Experience in nucleotide isolation, purification, and quantification.
11. Experience in mRNA and protein quantification methods including qPCR and western blotting.
12. Experience in epigenomic techniques including ChIP-seq and ATAC-seq.
Desirable
1. Experience in recent epigenomic techniques including CUT&Tag, CUT&RUN, and Hi-C.
2. Experience in using CRISPR gene-editing techniques.
3. Desire to learn how to analyze epigenomic data.
Attributes and Behaviour
1. Works collaboratively with team members, respecting their expertise.
2. Sets priorities in conjunction with team objectives.
3. Has a positive attitude and strives to improve ways of working.
4. Utilizes face-to-face communication regularly.
5. Demonstrates good time management skills.
Desirable
1. Takes responsibility for maintaining and training others on communal equipment.
2. Seizes opportunities to expand responsibilities and expertise.
Qualifications
A PhD (or nearing completion) in cancer/leukaemia research. Those nearing completion will be offered the role as Research Assistant, while those with a PhD will be offered the role as Research Associate.
Newcastle University is a global University committed to diversity and inclusion. We value the contributions of all employees and encourage applications from individuals who can complement our existing teams.
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