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Investigator, Protein Design and Informatics
Site Name: UK - Hertfordshire - Stevenage, USA - Massachusetts - Cambridge, USA - Pennsylvania - Upper Providence
Posted Date: Dec 10 2024
As an Investigator in the Protein Design & Informatics (PDI) team, you will focus on developing, integrating, and embedding advanced computational methods and predictive in silico models that accelerate discovery of medicines. Included in the larger Data & Predictive Sciences department, you'll be working daily with a diverse group of data/ML scientists, cheminformaticians, bioinformaticians, and many others, to impact from target discovery to the clinic - all stages of a therapeutic project.
Data & Predictive Sciences will only be successful by working in close collaboration with Research Technologies, Therapy Areas, GSK Tech, AIML, Vaccines, Risk & Compliance, and across lines within the function itself, and by developing and fostering a high-performing team culture of collaboration, curiosity, consistency, agility, quality, peer review, and continuous improvement with a relentless focus on creating medicines for patients.
We create a place where people can grow, be their best, be safe, and feel welcome, valued, and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.
We embrace modern work practices; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.
In this role you will:
* Work with partner functions to generate, validate, and integrate sequence-/structure-based generative AIML models for the de novo design and multi-objective optimization of tool and therapeutic biologics, such as antibodies, antigens, peptides, ADCs, and oligonucleotides.
* Innovate, develop, and apply predictive models for protein design and developability engineering, utilizing large-scale NGS, patient-derived, and other proprietary in-house and external data sources.
* Build agent-orchestrated, integrated Design-Make-Test cycles with automated platforms generating quality data at scale.
* Identify and advocate for the opportunities afforded by scientific computation and platform automation and champion a "predict-first" culture by maximizing use of predictive technology in experimental lines.
* Collaborate with external groups to further develop protein engineering computational methods.
Why you?
Basic Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:
* PhD or equivalent in Bioinformatics, Physics, Chemistry, Computer Science, Structural Biology, or related fields.
* Experience in protein structural or sequence analysis.
* Experience in one or more programming languages (e.g. Python, C/C++).
* Demonstrated ability to work as team lead or member; ability to work/lead effectively in a matrix environment.
* Demonstrated evidence of working across scientific and technical disciplines to deliver impactful solutions that drive project progression.
Preferred Qualifications & Skills:
Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:
* Experience developing or applying modern ML architectures for sequence- or structure-based protein design models (LLMs, diffusion models, flow-matching, GNNs, etc.).
* Experience predicting and analyzing protein-protein interactions and surfaces for design.
* Experience with engineering production-ready robust and scalable scientific workflows.
* Experience analyzing antibody repertoires for sequence- and structure-based design.
* Experience predicting structures of RNA or nucleic acid-protein complexes.
* Experience with molecular simulation techniques.
* Demonstrated learning agility, and scientific curiosity while maintaining focus on driving greater impact in the face of uncertainty and change.
* Ability to generate conclusion reports, present data in team meetings and participate in writing of abstracts and publications for the scientific community.
Closing Date for Applications - 23 Dec 2024 (COB)
Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We're uniting science, technology and talent to get ahead of disease together.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class (US only).
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391.
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