Research Fellow in Structural Mass Spectrometry
Are you an ambitious researcher looking for your next challenge? Do you have an established background in native mass spectrometry or HDX-MS? Do you want to further your career in one of the UKs leading research intensive Universities?
In this project, funded by a BBSRC Pioneer award, you will develop new mass spectrometry tools based on native MS and hydrogen/deuterium exchange (HDX) to elucidate structure-function relationships of oligonucleotides (OGN). Short DNA and RNA sequences can provide interaction motifs for proteins and antibody-like high-affinity binding (aptamers), but they can also be dynamic and partly unstructured. Recently there has been a surge of interest in OGNs and their derivatives for potential use as drugs and vaccines, but also as targets of pharmaceutical intervention. Currently our insights and toolkit are limited: many sequences are either too small for cryo-EM or too dynamic to easily yield x-ray structures.
Structural MS methods are well established for protein conformation and interactions but lacking for OGNs: here you will develop native MS, native top-down fragmentation, ion mobility and HDX-MS together with limited digestion and LC-MS approaches to pioneer applications to questions of higher-order structure (folding) and deliver exceptional insights into conformational dynamics and lipid and ligand interactions. Do you have a background in native MS and/or HDX-MS? Then this exciting project could be for you, as a pioneer developing new tools for the study of dynamic oligonucleotide structures of biological interest, in collaboration with colleagues at Leeds and Bristol.
Please note: If you are not a British or Irish citizen, you will require permission to work in the UK. This will normally be in the form of a visa but, if you are an EEA/Swiss citizen, this may be your status under the EU Settlement Scheme
Please note that this post may be suitable for sponsorship under the Skilled Worker visa route but first-time applicants might need to qualify for salary concessions. For more information, please visithttps://www.gov.uk/skilled-worker-visa
•26 days holiday plus approx.16 Bank Holidays/days that the University is closed by custom (including Christmas) – That’s 42 days a year!
•Generous pension scheme plus life assurance– the University contributes 14.5% of salary
•Health and Wellbeing: Discounted staff membership options at The Edge, our state-of-the-art Campus gym, with a pool, sauna, climbing wall, cycle circuit, and sports halls.
•Personal Development: Access to courses run by our Organisational Development & Professional Learning team.
•Access to on-site childcare, shopping discounts and travel schemes are also available.
And much more!
To explore the post further or for any queries you may have, please contact:
Professor Frank Sobott, Chair in Biomolecular Mass Spectrometry
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