At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person. AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we are more than one of the world's leading pharmaceutical companies.
We are seeking a motivated and independent Senior Scientist with demonstrated experience and expertise in Cellular Therapy, Immunology, and/or Immuno-Oncology to join our rapidly growing Cell Therapy Team. You will use your experience in T-cell and myeloid-cell biology to contribute to the advancement of innovative Cell Therapy products by designing and conducting laboratory experiments, developing methodology, and generating and interpreting scientific data in a collaborative environment. You will be based in Gaithersburg, MD and will report to the Associate Principal Scientist.
Responsibilities
* Conduct hands-on drug discovery research experiments independently
* Assess and report data with a clear understanding of its implications within the overall context of drug discovery, independently formulate conclusions, and determine future experiments
* Provide technical instruction to the team and allocate administrative work
* Work collaboratively in a matrix environment
* Share relevant external published papers with peers
* Prepare and deliver presentations within the Cell Therapy Unit and across other functions
* Ensure own work, and work of peers, are compliant with relevant internal AstraZeneca standards and external regulations
Education and Experience
* Bachelor's degree in Immunology or relevant disciplines with 7+ years' experience, or Master's degree with 5+ years or a PhD with 2 years relevant experience.
* At least 3 years of experience in Cellular Therapy, Immunology, or Immuno-Oncology
Essential Skills
* Well-developed understanding and expertise in cellular and molecular biology of immune cells
* Expertise in fibroblast biology or relevant in-vitro/in-vivo models or in T-cell genetic engineering platforms
* Hands-on expertise in T-cell functional characterization assays such as in vitro cytotoxicity, proliferation, cytokine measurement
* Proficiency in transfection/transduction, expansion, and cell culture of tumor cell lines and primary T-cells
* Proficiency with multi-parameter flow cytometry (Immunostaining, acquisition, and analysis)
* Ability to drive projects to completion in a team environment
Desirable Skills
* Expertise in myeloid cell biology and in vitro/in vivo models
* Expertise in T-cell mitochondrial metabolism
* Expertise in omics technologies and data analysis
* Experience in drug development in an industry setting
* In vivo experience including animal handling, mouse tumor models, standard routes of dosing and engraftment, tissue harvest and processing
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