Applications are invited for a highly motivated and curiosity-driven postdoctoral Research Associate to join the Crossley Group, located in the Cancer Research UK Cambridge Institute at the University of Cambridge. The Institute is core-funded by Cancer Research UK and has state-of-the-art research facilities for over 20 research groups to undertake world-class research into all aspects of cancer biology. About the Role RNA-DNA hybrid structures called R-loops form on the genome during transcription and regulate genomic processes. However, dysregulation of R-loops can threaten genome maintenance and has been linked to cancer, neurodegeneration and autoimmunity. The Crossley Group is concerned with investigating, at the molecular level, how R-loops and RNA-DNA hybrids become pathological, impacting genome stability and innate immunity. We ultimately aim to harness RNA-DNA hybrid molecules, and cellular responses to them, for cancer detection and new therapeutic opportunities. We recently discovered that dysregulation of R-loop metabolism by cancer-associated mutations leads to the excision of R-loops. Excised RNA-DNA hybrids are exported from the nucleus and build up in the cytoplasm of cells, activating an innate immune response (Crossley et al., Nature 2023). We are seeking candidates to gain mechanistic and translational insights into this novel and fascinating population of nucleic acids, incorporating one or more of the following areas: Genome biology and cellular dynamics of RNA-DNA hybrids, e.g their biogenesis from oncogene activation, retroelements and mitochondria. RNA-DNA hybrids in innate immunity and cellular responses e.g. senescence. Extracellular RNA-DNA hybrid release. Developing genomics and computational approaches for interrogation of RNA-DNA hybrids in cells and patient samples Candidates are expected to be largely independent, highly motivated and must have a PhD in biological sciences (or be close to completion). Candidates should have strong experience in biochemistry and molecular biology and a keen interest in RNA/genome biology. An excellent track record (evidenced by scientific publication commensurate with experience) is essential, preferably in one of the following areas: genome stability, RNA biology, chromatin biology, innate immunity, genomics or cancer biology. We combine wet lab and computational approaches, so experience in genomics and bioinformatics is desirable. Applicants should have excellent written and spoken English communication skills and demonstrate excellent organisation. Please send applications in the following format: a CV; the names and contact details of two referees; and a one/two-page cover letter explaining why you wish to be considered for the post, and your laboratory experience to date. Please do not send academic certificates at this stage. Fixed-term: The funds for this post are available for 2 years in the first instance. Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check. Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38, £34,132) moving to Research Associate (Grade 7) upon confirmation of their PhD award. Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online. If you have any queries regarding the application process or queries relating to this vacancy, please contact: mailbox-hrcruk.cam.ac.uk. Please quote reference SW45399 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Further information Further Particulars Apply online