Organisation/Company: KINGS COLLEGE LONDON
Research Field: Medical sciences
Researcher Profile: Recognised Researcher (R2), First Stage Researcher (R1)
Country: United Kingdom
Application Deadline: 6 Mar 2025 - 00:00 (UTC)
Type of Contract: Other
Job Status: Full-time
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description
About us
The Centre for Craniofacial & Regenerative Biology at King’s College London is one of the leading centres for Craniofacial Biology worldwide. Our research focuses on craniofacial and stem cell biology, innovative approaches to regeneration and repair, and big data approaches to understand the complexity of development and disease. The Centre offers a vibrant, collaborative, and interactive research and teaching environment in the heart of London.
About the role
A research technician is required to provide laboratory support for a project on “Mechanisms of Ventral Closure”. Ventral closure (VC) is a late morphogenetic event in embryonic development whose failure leads to the birth defects omphalocoele and gastroschisis. The project will investigate how VC happens or fails, specifically the cellular events and molecular regulators that make the abdominal wall grow around the viscera.
The technician will work in the Jeremy Green and Philippa Francis-West labs at King’s College London, which are well-established and located in the supportive environment of the Centre for Craniofacial Regenerative Biology on the Guy’s Hospital Campus.
The technician will be responsible for establishing and maintaining colonies of mice expressing fluorescent markers and genetically modified mice causing VC defects. Additionally, the technician will contribute to the research on the project and support the cellular, molecular, and immunohistological work, including explant culture and data analysis of cell proliferation, cell death, and cell shape in the abdominal wall.
The technician will work closely with the co-investigator Dr Caroline Formstone and the Postdoc to aid project progression. Experience in mouse work is essential, and an active Home Office Personal Licence or equivalent is highly desirable. Experience in molecular techniques and/or microscopy will be an advantage.
Responsibilities will include general lab management tasks such as consumables ordering and lab database maintenance.
This is a full-time, fixed-term contract for 12 months.
About you
To be successful in this role, candidates should have the following skills and experience:
* BSc in Biomedical Sciences or equivalent, including knowledge of genetics
* Hands-on experience working with live mice or similar animals
* Excellent written and verbal communication skills
* Ability to work in a multidisciplinary team
* Organised record keeping and experimental planning
* MSc or PhD level experience in a biomedical sciences subject
* Home office personal licence for working with mice or similar
* Experience in mouse colony maintenance
* Experience in embryology or organ culture
* Experience of molecular biology techniques such as PCR and immunofluorescence
Application Process
We ask all candidates to submit a copy of their CV and a supporting statement detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.
This post is subject to Occupational Health clearances.
Grade and Salary: £35,505 including London Weighting Allowance
Job ID: 106889
Close Date: 06-Mar-2025
Contact Person: Professor Jeremy Green
Contact Details: jeremy.green@kcl.ac.uk
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