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Senior Research Fellow - Bioinformatics – Extrachromosomal DNA and Tumour Evolution Scientist, London
Client:
Location: London, United Kingdom
Job Category: Other
EU work permit required: Yes
Job Reference:
Job Views: 4
Posted: 14.03.2025
Expiry Date: 28.04.2025
Job Description:
About the role
We are seeking a collaborative and self-motivated bioinformatician post-doctoral fellow to work on extrachromosomal DNA (ecDNA) in a vibrant and highly collegiate environment. ecDNA are circular genomic structures that can drive ultra-high copy number amplification and correlate with poor clinical outcomes, yet their evolution, detection, and targeting remain largely unclear. This project aims to analyse ecDNA evolution over time using single-cell RNA/ATAC sequencing and to develop a ctDNA-based approach for detecting and monitoring ecDNA to support biomarker and treatment development.
The project will leverage existing whole genome sequencing data from multi-region matched primary and metastatic tumours from the TRACERx lung cancer evolution and PEACE research autopsy programmes and will be part of the eDyNAmiC Cancer Grand Challenge.
Prof. Mariam Jamal-Hanjani is Principal Investigator of the TRACERx study at UCL, and Chief Investigator of the PEACE study. The Jamal-Hanjani Lab is a multi-disciplinary group of passionate and determined individuals who will provide the successful candidate with a stimulating and conducive environment to participate and grow as a scientist. The research in the lab is conducted in close collaboration with local and international scientists and clinicians, especially across the TRACERx and PEACE consortia and the CRUK Lung Cancer Centre of Excellence. These collaborative environments will provide the successful candidate with opportunities to learn from a large network of talented professionals.
The position will be available for 2 years in the first instance.
About you
The successful applicant should have a proven track record of publications, have previous experience with genomics data analysis, be fluent in at least one of the following programming languages: C++, Python or R, and will have strong skills in the field of genomics and desirably one or more of the following: tumour biology, ctDNA/ blood-based biomarkers, evolutionary biology, statistics and mathematics.
What we offer
As well as the exciting opportunities this role presents we also offer some great benefits some of which are below:
* 41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days)
* Defined benefit career average revalued earnings pension scheme (CARE)
* Cycle to work scheme and season ticket loan
* On-site gym
* Enhanced maternity, paternity and adoption pay
* Employee assistance programme: Staff Support Service
* Discounted medical insurance
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