Salary The starting salary will be from £33,232 per annum pro rata on Grade E, depending on qualifications and experience. Contractual Hours 18.25 Package Generous holiday allowances, flexible working, pension scheme and relocation package (if applicable). Job Category/Type Research Position Overview The Faculty wishes to recruit a Graduate Research Assistant to support the work of Prof Frank Vollmer and Dr Daniel Kattnig. This Leverhulme Trust funded post is available from January 2025 (initially for a 6 month appointment which can be extended, subject to approval). Project Title Understanding Nature’s Ultra-Weak Photon Emissions About the Project Imaging neuronal activity at cellular resolution across large areas is key to understanding higher-order neural processes and brain functions. Traditional neuroimaging techniques rely on genetically introduced fluorescent markers to visualise calcium signals. However, this project aims to harness ultra-weak spontaneous photon emissions (UPE) or biologically activated luminescence (BAL), naturally occurring in active neurons, as a non-invasive neuroimaging method. This interdisciplinary project will focus on the marine ragworm Platynereis dumerilii, an established model in neuroscience, to develop a novel single-photon detection approach for neuroimaging. Key objectives include: Investigating the luminescent neuroprotein Cryptochrome (Cry), believed to play a role in neuronal activity, circadian rhythms, and magneto-perception. Developing methods to detect UPE/BAL emissions from neurons in the worm’s pacemaker circuit and linking them to brain activity patterns. Exploring how magnetic fields influence BAL through pathways involving Cry, particularly in regions near the eyespot of Platynereis. Project Leadership The project is led by an interdisciplinary team: Prof. Vollmer (Physics of Nano and Quantum Sensing) Dr. Kattnig (Biophysics and Quantum Biology) Role Description We are seeking a motivated Graduate Research Assistant (GRA, 0.5 FTE) to contribute to this cutting-edge research. The role will span two main phases: Phase I: Conduct single-molecule sensing experiments using neuroprotein Cryptochrome. You will receive training in advanced optical techniques and routinely perform single-molecule experiments. Phase II: Perform single-photon detection experiments on Platynereis dumerilii to study UPE/BAL emissions and their correlation with neuronal activity. These well-established protocols will enable high-sensitivity measurements of naturally emitted photons. Candidate Requirements A background in physics, biophysics, neuroscience, or a related discipline. Strong interest in interdisciplinary research bridging advanced optical methods and neuroscience. Eagerness to learn cutting-edge techniques in single-photon detection and neuroimaging. Experience in optical experiments, microscopy, or neuroscience techniques is desirable but not essential, as training will be provided. What We Offer Mentorship from leading researchers in physics, biophysics, and neuroscience. Access to state-of-the-art facilities and training in advanced optical and single-photon detection techniques. Opportunity to contribute to pioneering neuroimaging methods with potential applications in brain research and magneto-sensory biology. About You The successful applicant will be able to present information on research progress and outcomes, communicate complex information, orally, in writing and electronically, and prepare proposals and applications to external bodies. Applicants will be educated to first degree level or possess an equivalent qualification/experience in a related field of study or equivalent experience and be able to demonstrate sufficient knowledge in the discipline and of research methods and techniques to work within established research programmes. Further Information For further information please contact Prof Frank Vollmer, f.vollmerexeter.ac.uk or telephone (01392) 724771.