Redx Pharma is a clinical-stage biotechnology company focused on the discovery and development of novel, small molecule, highly targeted medicines for the treatment of fibrotic diseases and cancer; progressing a pipeline of novel, differentiated drug candidates against biologically validated targets in areas of high unmet medical need, including IPF and fibrostenotic Crohn’s disease. The Company has a strong track record of discovering new drug candidates through its core strengths in medicinal chemistry and translational science, with six Redx discovered molecules now in the clinic. Alongside, its wholly owned assets zelasudil, RXC008, zamaporvint and RXC009, the Company has significant partnership deals with both AstraZeneca and Jazz Pharmaceuticals. The Role As a laboratory-based scientist you will be trained to provide support to Redx projects by performing in vitro and in vivo assays that are required to understand the ADME properties of potential drug candidates. This will include assessment of physicochemical properties of compounds as well as DMPK profiling of compounds. Responsibilities To undertake, under supervisions, various in vitro ADME profiling assays such as metabolic stability (microsomes, hepatocytes) and binding (plasma protein binding, foetal calf serum binding, tissue binding etc). To undertake, under supervision, various physicochemical profiling assays such as solubility (kinetic and thermodynamic), log D and chemical stability. To provide support, under supervision, for in vivo ADME analysis (e.g. bioanalysis). To learn the routine operation, maintenance and use of a Waters TQS LC-MS/MS and HPLC-uv systems. Requirements BSc or MSc in a relevant discipline or equivalent experience. Some experience of working in a laboratory. An understanding of liquid chromatography and mass spectrometry in either a bioanalytical or pharmaceutical analysis context. An understanding of in vitro ADME assays. A general appreciation of the essential elements of the drug discovery process. Competencies Results orientation Innovation & Creativity Planning & Organising Communication Skills Interpersonal skills/Team orientation Motivation Thoroughness In return, we will offer you the opportunity to work at an exciting drug discovery company where you will get exposure to a broad range of activities and develop your drug discovery skills.