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Site: Great Ormond Street Hospital for Children NHS Foundation Trust
Town: London
Salary: £54,320 - £60,981 per annum inclusive
Salary period: Yearly
Closing: 24/04/2025 23:59
Job overview
Applications are invited from State Registered Clinical Scientists in Genomics; scientists close to registration will also be considered.
The scientist will be joining the team at the North Thames Rare Disease Laboratory Hub at Great Ormond Street Hospital. We are seeking enthusiastic, self-motivated scientists with experience of genomic service delivery and a sound understanding of molecular and cytogenetic techniques and analysis. Accomplished communication and organisational skills are required.
The successful candidate will join the postnatal team at the North Thames Rare Disease Laboratory Hub at Great Ormond Street Hospital. Experience of cytogenetic analysis and interpretation including karyotyping and copy number analysis is essential.
We support trained scientists who wish to adopt flexible and/or hybrid working patterns. For Clinical Scientists, after a successful probation period, there is a requirement to work on-site for 40% of working hours.
Main duties of the job
The Rare Disease Laboratory has an establishment of approximately 160 including technologists, clinical scientists, translational scientists, bioinformaticians and administrative support staff. Along with two Clinical Genetics teams we form a strategic Genetics Unit within the hospital and provide North London with a Regional Genetics Service serving a population of approximately 10 million. Having been awarded 11 specialisms in the NHSE Genomic Medicine Service the laboratory provides an in-house diagnostic service for cancer, molecular and cytogenetic testing in accordance with the NHS England Genomic Test Directory. Cytogenetic testing is provided for both prenatal and postnatal samples using SNP microarray, karyotyping, FISH, and qPCR. Molecular testing includes next generation sequencing and targeted tests. We are also engaged in the delivery of the NHSE GMS Whole Genome Sequencing programme for our North Thames patients.
We are involved in a number of collaborative research and development projects with colleagues at the UCL Institute of Child Health and Institute of Neurology as part of the UCL Partners Academic Health Sciences Centre. We provide a DNA preparation and storage service in support of many of these projects.
GOSH is committed to recruiting the best person for the job, based solely on their ability and individual merit as measured against the criteria for the role; through a process that is fair, open, consistent and free from bias and discrimination.
We are committed to being a diverse and inclusive employer and foster a culture where all staff are valued, respected and acknowledged. All applicants will receive consideration for employment without regard to race, colour, national origin, religion, sexual orientation, gender, gender identity, age, disability status or length of time spent unemployed.
We particularly welcome applications from BAME communities, people with disabilities and/or long-term health conditions and LGBT+ community members.
We have policies and procedures in place to ensure that all applicants and employees are treated fairly and consistently. We are proud to be accredited as a Disability Confident Employer, a member of Business Disability Forum and a Stonewall Diversity Champion.
We have active and Executive supported BAME, LGBT+ and Allies, Disability and Long-Term Health Conditions and Women’s staff networks. Staff networks are employee-led groups formed around interests, issues and a common bond or background. Staff network members create a positive and inclusive work environment at Great Ormond Street Hospital by actively contributing to the Trust’s mission, values and efforts specific to inclusion. All of our staff networks are open to any employee.
Detailed job description and main responsibilities
The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachment/s below.
Person specification
GOSH Culture and Values
* Our Always values
* Knowledge and Understanding of diverse backgrounds and perspectives
* Understanding of Diversity and Inclusion challenges in the workplace
* Demonstrable contribution to advancing Equality, Diversity and Inclusion in the Workplace
* First or Second Class Degree in Molecular Biology, Genetics, Biochemistry or related subject
* HCPC Clinical Scientist Registration Certificate
Experience/Knowledge
* At least 2 years postgraduate experience in a genomics laboratory
* Extensive knowledge of clinical genomics and a demonstrable track record in the delivery of a diagnostic service
* Knowledge of structural chromosome rearrangements and segregation, CNV analytical methods and clinical applications OR Knowledge and experience of molecular variant classification in accordance with ACGS guidance and their application for all modes of inheritance
* Track record of scientific Publications/ presentations
* Evidence of supervising/training other staff
* Experience with laboratory information and quality management systems
Skills/Abilities
* Skilled in Next Generation Sequencing Applications / Sanger Sequencing and/or genomic CNV analysis by use of G banded chromosomes / FISH / Microarray
* Good organisational and interpersonal skills. Willing to adapt to changes in workflow and organisation
* Computer literate, including use of Genetic databases, analytical software, variant classification
* Able to communicate effectively both verbally and in writing (by email and by appropriate documentation)
* Able to write protocols
* Background in cytogenetic and molecular procedures
Please be advised that:
The recruitment process for all admin and clerical roles at Bands 2-4 will be a two stage recruitment process whereby shortlisted candidates will undertake an online literacy, numeracy, ICT and typing test. Only those candidates who pass the competency test will proceed to a formal interview.
The closing date given is a guide only. There may be some occasions where we have to close a vacancy once sufficient applications have been received. It is therefore advisable that you submit your application as early as possible to avoid disappointment.
Only those candidates who clearly demonstrate how they meet the person specification criteria for this post will be shortlisted. Please note that where high volumes of applicants have been received, additional criteria may on occasion be used to determine the final shortlist.
We are an accredited Living Wage Employer.
Employer certification / accreditation badges
You must have appropriate UK professional registration.
The postholder will have regular contact with vulnerable people and as such this post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975 (Amendment) (England and Wales) Order 2020 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service to check for any previous criminal convictions.
Name: Dorte Wren
Job title: Consultant Clinical Scientist for Cancer NT-GLH
Email address: dorte.wren@gosh.nhs.uk
Telephone number: 02074059200
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