This is a 12 month fixed term contract positon. Based at Alderley Park, Medicines Discovery Catapult is a national Life Sciences service dedicated to turning drug discovery into commercial breakthroughs. We accelerate the development of science, and where there are areas of unmet patient need, we stimulate innovation. By transforming drug discovery, we can improve patient lives, increase the impact of the UK Life Sciences sector, and create a healthier society and economy. Our interventions work. Since we started, we have helped over 300 companies raise over £1bn of R&D investment. We seek passionate individuals who are eager to collaborate, innovate, and make a tangible difference in the field of drug discovery. Together, we can unlock new therapies, enhance patient outcomes, and ensure that the UK remains at the forefront of life sciences innovation. If you are ready to make an impact, we invite you to be part of our journey. The values of the Catapult are: Excellence – we continually strive to deliver the best solutions for our partners and for each other. In everything we do, we instil confidence. Integrity – Our strong commitment to what we do and why we are here drives us to do the right thing for our partners and each other. Community – We’re a strong team, we work well together, and we respect each other. Innovation - We’re driven by the need to make a difference. We constantly look for ways to drive change in our sector and how we work. Role purpose: Translational imaging is a key pillar in our science strategy, and we have established a suite of preclinical imaging technologies (PET, CT, Gamma counting, Ultrasound, Luminescence) that we deploy in tandem with advanced radiochemistry to advance our collaborators’ drug development programmes. We are building our capability in the characterisation of radiopharmaceuticals, an exciting new modality for oncology drug discovery, and this role is essential in the delivery of our growing radiopharmaceutical project portfolio. The role of Scientist – Translational Imaging would suit a highly-organised, experienced in vivo scientist who either has experience in delivering pre-clinical studies, preferably in the oncology area, or is highly motivated to develop and refine their skill sets to deliver these studies. The individual will provide high quality lab support to studies that are designed to monitor, assess and characterise the biodistribution and efficacy of drug molecules, including complex medicines and biologics. Specifically, they will take a leading role in managing tumour xenograft growth, animal health monitoring, and ensuring written records for Home Office compliance and Environment Agency standards (radioactivity). Attention to detail, a collaborative mindset, and flexibility to work on a range of projects will be essential. They will work closely with colleagues in interdisciplinary project teams and will make a significant contribution to delivery of the MDC Translational Imaging project portfolio. Main duties and responsibilities: Design and deliver high quality experimental plans for partnered Translational Imaging projects, delivering high quality data in a complex and time pressured research environment. Effectively analyse and interpret experimental results, deploying new approaches as required. Implement new approaches and workflows to address project questions and build new lab capability. Generate study data for analysis in a concise and organised form. Carry out Xenograft tumour growth assessment and evaluation. Carry out tissue removal for ex vivo analysis. Work closely with other scientists on projects to ensure that models are viable and that reagents are prepared in a timely and appropriate manner. Identify potential problems associated with experiments and implement solutions in agreement with line manager and other team members. Adhere to safe and effective lab processes and to governance requirements, including experimental. record keeping and compliance with procedures required for working with open bench radioactivity. Apply effective communication and research collaboration skills, working with a wide range of colleagues within and outside the Translational Imaging team. Able to work autonomously on projects, referring to more senior colleagues as required for direction and support. Essential qualifications, experience and knowledge: A degree in a bioscience discipline (or other relevant degree) plus significant lab experience working in a bioscience or medicines discovery environment; or significant and demonstrable relevant experience in a laboratory environment. Experience in a range of relevant experimental methods. A track record of delivering high quality results. Ability to work effectively on multiple projects simultaneously in a highly collaborative and interdisciplinary environment. Strong attention to detail with excellent communication skills. Extensive experience in animal handling & husbandry. Experience of working with animal models of disease. Proficiency in a range of fundamental skills, including tumour assessment, tissue removal and reporting clinical signs. Knowledge and experience of welfare assessment, including the use of appropriate terms for the recording of clinical signs. Awareness of Home Office project licence and in-vivo compliance. Accurate record keeping for legislative, regulatory, and scientific purposes. A flexible approach to working hours as required to ensure that we meet our obligations in relation to adherence to regulations and compliance with external requirements. Highly motivated and enthusiastic and exhibiting effective time management. Proficient in the use of computers including experience of MS office suite of programs. Desirable qualifications, experience and knowledge: Home Office licence (PIL A, B) Experience in various dosing routes, cell implantation and blood collection. Experience of working with open bench radioactivity and knowledge of the regulations in place for use. Industry experience, working in the pharmaceutical, biotech or CRO sector. Closing date: Tuesday 7th January 2025 Please note the closing date for applications may be brought forward if a high volume of applications are received.