Job Details: Research Scientist - Autoimmune Diseases
Vacancy Name: Research Scientist - Autoimmune Diseases
Vacancy No: VN453
Employment Type: Full Time
Location: Oxford, UK
About the Company: Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases, and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We strive to create a diverse and inclusive workplace, while seeking talented individuals to work with us across the many functions that will allow us to deliver new medicines to transform the lives of patients.
Key Responsibilities:
• Independently conduct and interpret cellular assays and studies to probe the effect of ImmTAAIs on immune cells in the context of autoimmunity.
• Develop new in vitro models to explore efficacy of new ImmTAAI effectors function.
• Conduct cellular screening assays to support optimisation of ImmTAAIs.
• Support studies to demonstrate ImmTAAIs proof of concept in vitro.
• Contribute to the autoimmune biology platform by isolating and characterising various immune cells, participating in the generation and expansion of T cell clones, maintaining cancer cell lines and primary cells.
• Interpret and communicate data to colleagues and peers, actively participate in team and project meetings.
• Gain understanding of relevant literature and develop knowledge of the pathophysiology of Autoimmune diseases.
• Contribute to routine lab maintenance and organisation.
Qualifications:
Essential:
• PhD in Immunology or Cellular Immunology, with 1 year of relevant postdoctoral experience preferably in industry.
• Background in inflammation and autoimmune immunology.
• Understanding of the drug discovery process.
• Ability to run and design cell-based assays / functional assays to address key scientific questions.
• Skilled in isolation and expansion of various immune cells (CD8+ and CD4+ T cells, Tregs, and monocytes).
• Experience in immunology techniques such as NFAT luciferase reporter assay, ELISA, MSD cytokine analysis and T cell killing assays.
• Experienced in cancer cell and primary cell line culture.
• High attention to detail, good time management skills, and communication skills.
• Strong team player with the ability to work independently.
• Capability to multitask and handle different activities concurrently.
• Excellent oral and written communication skills.
Desirable:
• Proficient in Flow cytometry.
• Experience with confocal microscopy techniques.
• Peer-reviewed publications.
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