About us
The role is to provide specialist expertise as a chemist and to perform radiopharmaceutics research within a multidisciplinary EPSRC-funded Programme: Next Generation Radiochemistry for Molecular Imaging with Radionuclides (MITHRAS), based at Imperial College London, King's College London and the University of Southampton.
The team will include specialists in radionuclide production, nanodrug and cell therapy researchers, organic and inorganic chemists and radiochemists, and molecular imaging biologists, and will be embedded within a wider collaborative network comprising the Department of Imaging Chemistry and Biology in the School of Biomedical Engineering & Imaging Sciences at King's College London, and the Department of Chemistry at Imperial College, and a network of major internal and external collaborations with other major London universities and hospitals.
The aim of the programme is to develop new chemistry for fast, accessible synthesis of radiopharmaceuticals, and translate this into clinically translatable products for imaging and radionuclide therapy.
About the role
This post holder will have the specific role of developing new radiometal chemistry i.e. designing organic ligands and inorganic coordination chemistry for a range of new and existing radiometals that will be subjected to preclinical evaluation, including imaging biology and radiochemistry.
We are looking for someone with a range of synthetic chemistry (inorganic and organic) and ideally, radiochemistry skills or experience in imaging sciences. This role will encompass varied responsibilities, including work on a wide range of collaborative projects. The post holder will develop new chemistry and chelators and use them to develop radiometal-based radiopharmaceuticals including complexes and bioconjugates, incorporating a range of different radiometals. In addition, the post holder will perform preclinical research in radiopharmaceutics, ideally including in vitro and in vivo biological studies and preclinical molecular imaging (mainly PET, SPECT, CT, but also potentially optical and MR). This work will involve collaborations with research groups across King's and Imperial and to drive the development and translation of radionuclide-based molecular imaging and therapy agents.
The post holder will be expected not only to perform projects within their specific remit but also to provide training, assistance and advice to other workers and collaborators. In particular, he/she will advise, support and train internal staff and students in the design and execution of experiments relating to molecular imaging, including radiosynthesis of tracers, in vitro biological evaluation, and in vivo molecular imaging. The role will be a basis for first-author publications on the development of innovative methodologies in this field as well as co-authoring user-led publications.
This is a full time post (35 Hours per week), and you will be offered a fixed term contract until 31 March 2025.
About you
To be successful in this role, we are looking for candidates to have the following skills and experience:
Essential criteria
1. PhD qualified in relevant subject area (or pending results)
2. Experience in synthetic organic and inorganic chemistry
3. Experience in imaging chemistry
4. Experience in metal coordination chemistry and chelator design
5. Practical experience within a research environment and publication in relevant and refereed journals
6. Computer literate with a good knowledge of different computer programs with experience in data presentation and statistical analyses
7. Experience of one or more chemical/biological aspects of molecular imaging (e.g. chemistry, radiochemistry, molecular biology, cancer biology etc.)
8. Ability to conduct a detailed review of recent literature and develop and apply new concepts
Desirable criteria
1. Experience in handling and safety of radionuclides including gamma, alpha, beta and positron emitters at medical diagnostic and therapeutic activities
2. Experience of biomolecule labelling methods, use of bifunctional chelators, in vitro and in vivo testing of radiopharmaceuticals, cell labelling, using a variety of radionuclides
3. Creative approach to problem-solving
4. Excellent verbal communication skills and the ability to deal with a wide range of people
5. Excellent written communication skills and the ability to write clearly and succinctly for publication
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