Nombre del sítio: UK - Hertfordshire - Stevenage
Fecha de publicación: Mar 5 2025
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Please note this position is lab based.
For the newly founded NIVP team, we are looking for an Investigator who enjoys developing new in vitro models to create positive impact on patients. NIVP is part of the Oncology Translational Research (OTR) team, and we aim to network closely with the other teams within and outside OTRO to contribute to preclinical and clinical development programs within GSK Oncology TA. The successful candidate will be part of a team that is being established in both Berlin and Stevenage. The core competence of the group is the establishment of new organoid models and their use in translational research, ranging from chemosensitivity testing to molecular manipulations for biomarker identification and target validation projects.
Key responsibilities
This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following :
* Setting up cell culture protocols to grow and expand patient-derived organoids upon reception.
* Oversight and performing the cell culture/ expansion.
* Performing patient-derived organoids quality control steps (cell density, proliferation rate and cytotoxicity evaluation).
* Collecting and reporting data to the lab head.
* Executing and delivering of the project.
* Solving technical issue operate as part of a cross-functional project team.
Why you?
Basic Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:
* BSc in Cell Biology/Oncology or related
* Post doc experience or similar experience
* A multidisciplinary mix of training/expertise in Oncology and Cancer cell biology.
* Significant experience in cell culture techniques (primary samples/ patient-derived organoids), cytotoxicity analysis.
* Cellular and molecular Biology skills: cell isolation from human biopsies/samples; culture of normal and tumor cells from primary samples or immortalized cell lines; cell isolation from buffy coats; organoid establishment from fresh or frozen tissue; 3D culture in Matrigel or scaffolds (spheroids and organoids)
* Ability to communicate with team members from different backgrounds by training/discipline, as well as senior members of the GSK stakeholders/research partner units
* Ability to deliver high quality, consistent results in a timely fashion with a positive can-do and result oriented attitude
Preferred Requirements:
Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:
* MSc or PhD in Cell Biology/Oncology or related
* Background of immunology
* Experience in flow cytometry
* A track record of scientific Publication
* Experience in collaboration with biopharma
Closing Date for Applications – Wednesday 12th of March (COB)
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
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