Cancer Research UK Manchester Institute - Principal Computational Biologist
Job Title: Principal Computational Biologist
Category: Other
Closing Date: 24/11/2024
We are looking for a Principal Computational Biologist to join The National Biomarker Centre (NBC) to work on the optimisation and validation of our TOO classifier. You will work alongside our multidisciplinary team of clinicians, molecular biologists, and computational scientists on a Cancer Research UK funded project to develop CUPiD towards a clinically validated approach. The main area of focus will be the development and application of statistical/machine learning approaches to enhance classifier performance.
Background:
The National Biomarker Centre (NBC), in the Cancer Research UK Manchester Institute, is an acknowledged world leader in the study of minimally invasive biomarkers, or liquid biopsies, for improving cancer management. We have a highly interdisciplinary team working to develop a blood test to identify the tissue-of-origin (TOO) of tumours for patients diagnosed with a cancer of unknown primary (CUP).
About the role:
You will work on the optimisation and validation of our TOO classifier. The main area of focus will be the development and application of statistical/machine learning approaches to enhance classifier performance, for example through:
* Refinement of data augmentation strategies for generating training data sets;
* Multi-omic data integration, combining genomic and fragmentomic features alongside methylation profiles;
* Optimisation of classifier hyperparameters;
* Improved statistical models for normalisation of our genome-wide methylation sequencing data and for detection of differentially methylated regions.
The optimised classifier will then be validated in a large cohort of cfDNA samples from patients with known cancer types. This is an exciting opportunity to develop and apply computational methods to high-throughput data in a translational research project with a clear line of sight to clinical application.
About you:
You should have a PhD in Computational Biology/Bioinformatics, Statistics, Computer Science (or related discipline), or a relevant postgraduate degree in Computational Biology/Bioinformatics, Statistics, Computer Science or related discipline plus significant relevant experience. You will have significant experience in the development and/or application of statistical/machine learning methods, particularly supervised learning approaches, and demonstrable experience in areas of bioinformatics pertaining to the analysis of high-throughput data.
You will also have excellent communication skills and apply these skills to interdisciplinary collaborations. Experience of multidisciplinary teamwork would be beneficial.
Why choose the CRUK NBC?
The Cancer Research UK National Biomarker Centre is a leading and highly specialised translational research centre within The University of Manchester core funded by Cancer Research UK, the largest independent cancer research organisation in the world.
How to apply?
To apply for this position please visit our website.
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