Description UE07: £40,247.00 - £47,874.00 Per Annum. College of Medicine & Veterinary Medicine / Institute of Genetics & Cancer. Fixed Term Contract - Temporary. Full Time - 35 Hours Per Week. The Opportunity: Topo I-mediated genome damage in cancer and neurodegeneration Our recent work established that a topoisomerase causes genome damage at ribonucleotides embedded within DNA in cancer (Reijns et al, Nature 2022). Furthermore, this endogenous damage occurs frequently in normal tissues, with an associated mutational signature detected in ageing brains. This postdoctoral position is to investigate how and where this genome instability arises in replicating and non-replicating cells, to gain insight into its involvement in cancer and other human diseases. It is also likely to shed light on how DNA damage drives innate immune-mediated inflammation in Aicardi-Goutières syndrome. The post-holder will be part of a multidisciplinary team in the lab of Prof. Andrew Jackson, working in a cross-disciplinary environment that addresses both fundamental cellular processes and disease mechanisms. The lab is embedded in the Institute of Genetics and Cancer, a highly collaborative and supportive environment. The research group is internationally diverse and strongly competitive consistently publishing in high-level journals including 5 papers published in Science and Nature in the last 10 years. This post is full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns. We are also open to considering requests for hybrid working (on a non-contractual basis) that combines a mix of remote and regular on-campus working. The salary for this post is £40,247 to £47,874 per annum. Click here to view a copy of the full job description (opens new browser tab). Application Information Please ensure you include the following documents in your application: CV Cover letter As a valued member of our team you can expect: A competitive salary An exciting, positive, creative, challenging and rewarding place to work. To be part of a diverse and vibrant international community Comprehensive Staff Benefits, such as a generous holiday entitlement, competitive pension schemes, staff discounts, and family-friendly initiatives. Check out the full list on our staff benefits page (opens in a new tab) and use our reward calculator to discover the total value of your pay and benefits Championing equality, diversity and inclusion The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality. Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our right to work webpages (opens new browser tab) Key dates to note The closing date for applications is 3 March 2025. Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone. Interviews will be held in early March. The University is able to sponsor the employment of international workers in this role. If successful, an international applicant requiring sponsorship to work in the UK will need to satisfy the UK Home Office’s English Language requirements and apply for and secure a Skilled Worker Visa.