About Immunocore
We are a pioneering biotechnology company dedicated to developing and commercializing transformative medicines for patients with high unmet medical need in oncology, infectious diseases, and autoimmune diseases. Our research and development teams are internationally recognized as successful drug developers, creating an innovative powerhouse that addresses the big questions. We strive to create a diverse and inclusive workplace where talented individuals can collaborate to deliver new medicines.
Role Overview
The Principal Scientist In Silico Biologics Design will provide world-class expertise in machine learning to drive the establishment of robust in silico methodologies that integrate computational predictions with empirical laboratory data. Using our wealth of structural data, combined with further in-house and public domain data sets, the successful applicant will develop ML algorithms to impact the design of future drugs.
Key Responsibilities
* To develop and assess advanced machine learning (ML) models for novel antibody and TCR drug candidate optimisation and, looking to impact de novo drug design in the future
* Utilise our extensive in-house structural and specificity data sets to extract further value
* Work with colleagues across Research to identify training data from the public domain and help shape the development of our in-house data sets to support the optimisation of ML algorithms
Requirements
* Demonstrated ability to build and evaluate machine learning models
* At least 8 years of experience in antibody, TCR or biologics design, evidenced by a strong publication record
* Proficiency with protein ML models such as AlphaFold, ESMFold, RFdiffusion, MPNN
Benefits
We offer a competitive salary of $180,000 - $220,000 per year, depending on experience. Additionally, we provide opportunities for professional growth, collaboration with industry leaders, and access to cutting-edge technologies. Our team values innovation, trust, and collaboration, and we strive to create a dynamic work environment that fosters creativity and excellence.