Job id: 097245. Salary: £44,105 - £45,247 per annum, including London Weighting Allowance.
Posted: 17 October 2024. Closing date: 14 November 2024.
Business unit: Faculty of Life Sciences & Medicine. Department: Biomedical Engineering.
Contact details: Dr Alkystis Phinikaridou. alkystis.1.phinikaridou@kcl.ac.uk
Location: St Thomas’ Campus. Category: Research.
About the role
This exciting postdoctoral position is funded by a British Heart Foundation Project grant entitled “Molecular MRI signatures of fibrosis to detect heart failure and response to treatment”. The research aims to answer the clinically important question whether molecular MR imaging can provide readouts for precision imaging of cardiac fibrosis to detect adverse cardiac remodelling, hearts at risk of failing and monitor therapeutic response.
The candidate will work in an interdisciplinary team consisting of physicists, imaging biologists, chemists, and clinicians to develop novel MR imaging techniques for the non-invasive detection of cardiac fibrosis using new molecular imaging probes in preclinical models of heart failure. The research team is located at St Thomas´ Hospital in the Research Department of Cardiovascular Imaging which has access to 10 state-of-the-art clinical research scanners with field strengths varying from 0.55T, 1.5T, 3T to 7T.
The specific aims of the post will be to:
1. Devise and validate a heartrate-independent, motion-resilient and fast 3D free-running cardiac T1 mapping sequence with dictionary matching at a 3T clinical suitable for preclinical imaging.
2. Closely collaborate with an imaging biologist to test and validate the newly developed protocol for accurate molecular imaging of cardiac fibrosis in rodent models of heart failure.
This is a full time post (35 Hours per week), and you will be offered a fixed term contract for 1.5 years.
About you
To be successful in this role, we are looking for candidates to have the following skills and experience:
Essential criteria
* PhD awarded (or near completion) in Engineering, Physics, Computer Sciences or similar*
* Experience in Magnetic Resonance Imaging physics
* Experience in Magnetic Resonance image pulse sequence development and image reconstruction
* Experience in MATLAB, Python, C++ or similar
* Practical experience in acquiring MRI data in phantoms
* Ability to present scientific research in the form of papers, posters and oral presentations, conduct a detailed review of recent literature and organise own work with minimal supervision
* Excellent verbal and written communication skills and ability to work as part of a multidisciplinary research team, relying on and supporting others effectively
* Willingness to work out of normal working hours (including weekends) if the requirements of the project demand
Desirable criteria
* Practical experience in Magnetic Resonance pulse sequence development (Philips environment preferred)
* Practical experience in phantom, preclinical and/or human scanning with MR imaging
* Practical experience in a broad range of MRI techniques including CMR
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