Cancer Research UK Manchester Institute - Postdoctoral Scientist
Job Title: Postdoctoral Scientist
Category: Non-technical roles
Closing Date: 01/12/2024
We are looking for Postdoctoral Scientists to join Evangelos Giampazolias in his Cancer Immunosurveillance Group. The aim of this post is to address the mechanisms governing nutrient-host-microbiome interactions that permit systemic immune responses to cancer in mice and humans. You will work with in vivo mouse models, gut organoids or samples from cancer patients using spectral flow cytometry, microscopy, single-cell RNA sequencing, proteomics, and metabolomics in host cells and commensal species to identify instructive factors of microbiome-dependent cancer immunity.
* Starting salary: £32,868 - £42,717 (dependent upon qualifications and experience)
* Job Ref: MI/24/54
* Duration: fixed term up to 4 years with the potential to extend up to a total of 7 years (subject to successful reviews at Year 3 and 5)
About the role:
The aim of this post is to address the mechanisms governing nutrient-host-microbiome interactions that permit systemic immune responses to cancer in mice and humans. You will work with in vivo mouse models, gut organoids or samples from cancer patients using spectral flow cytometry, microscopy, single-cell RNA sequencing, proteomics, and metabolomics in host cells and commensal species to identify instructive factors of microbiome-dependent cancer immunity.
About you:
You will have a PhD in either immunology using mouse models or human tissues (preferentially in mucosal or cancer immunology) OR host-microbiome interactions in mice or human (preferentially gut microbiome).
Who we are:
In the Cancer Immunosurveillance group, we combine genetically modified mouse models, transplantable microbiome, and diets to disentangle complex nutrient-host-microbiome interactions that define immunity to cancer. Our vision is to identify microbiome-immune checkpoints that can be predictive of immunotherapy response and targeted to overcome immunotherapy resistance.
Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute (CRUK MI), an Institute of The University of Manchester, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK, the largest independent cancer research organisation in the world with access to outstanding laboratory and animal facilities including germ-free facilities as well as exceptional core services, including spectral and conventional cytometers, next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology, and mass-spectrometry. In spring 2023 the Institute moved into the new Paterson Building, a £150 million flagship purpose-built biomedical research centre directly attached to The Christie NHS Foundation Trust, in South Manchester. We are partnered with The Christie NHS Foundation Trust, one of the largest cancer treatment centres in Europe and Lydia Becker Institute of Immunology and Inflammation (University of Manchester), one of the largest Immunology centres in the UK.
How to apply?
To apply for this position please visit our website: https://www.cruk.manchester.ac.uk/recruitment/candidate/searchvacancies
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